ado-trastuzumab emtansine

Known as: T-DM1 cpd, Trastuzumab emtansine, Trastuzumab-MCC-DM1 Immunoconjugate 
An antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Antibody–drug conjugates (ADCs) are one of the fastest growing classes of oncology therapeutics. After half a century of research… (More)
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2016
2016
BACKGROUND Central nervous system (CNS) metastases represent a major problem in the treatment of human epidermal growth factor… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Patients with progressive disease after two or more HER2-directed regimens for recurrent or metastatic breast cancer… (More)
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Highly Cited
2013
Highly Cited
2013
PURPOSE Trastuzumab emtansine (T-DM1), an antibody-drug conjugate composed of the cytotoxic agent DM1 conjugated to trastuzumab… (More)
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2013
2013
Continued on page 564 Ado-trastuzumab emtansine approved for advanced breast cancer FDA and Genentech on February 22 announced… (More)
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Review
2011
Review
2011
Trastuzumab emtansine (T-DM1) is a human epidermal growth factor receptor (HER2)-targeted antibody-drug conjugate, composed of… (More)
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Highly Cited
2011
Highly Cited
2011
Trastuzumab emtansine (T-DM1) is an antibody–drug conjugate comprising trastuzumab and DM1, a microtubule polymerization… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Trastuzumab-DM1 (T-DM1) is an antibody-drug conjugate that uses trastuzumab to specifically deliver the maytansinoid… (More)
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Highly Cited
2004
Highly Cited
2004
Following the seminal publications of Rubin about thirty years ago, statisticians have become increasingly aware of the… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND During the development of heart failure (HF), the chief myocardial energy substrate switches from fatty acids to… (More)
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