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adenylyl cyclase type V

Known as: AC5 enzyme, adenylyl cyclase type 5 
 
National Institutes of Health

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Broader (1)

Adenylate Cyclase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
A Food and Drug Administration–Approved Antiviral Agent that Inhibits Adenylyl Cyclase Type 5 Protects the Ischemic Heart Even When Administered after Reperfusion
A Food and Drug Administration–approved antiviral agent, known as vidarabine or adenine 9-β-D-arabinofuranoside (AraA), has… Expand
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2016
2016
Homozygous GNAL mutation associated with familial childhood-onset generalized dystonia
Heterozygous loss-of-function mutations in the GNAL gene encoding the α subunit of the heterotrimeric G protein Golf (Gαolf) are… Expand
2015
2015
Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling
In the striatum, signaling via G protein-coupled neurotransmitter receptors is essential for motor control. Critical to this… Expand
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2015
2015
Overexpression of adenylyl cyclase type 5 (AC5) confers a proarrhythmic substrate to the heart.
Inhibition of β-adrenergic receptor (β-AR) signaling is one of the most common therapeutic approaches for patients with… Expand
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2013
2013
Similarly Potent Inhibition of Adenylyl Cyclase by P-Site Inhibitors in Hearts from Wild Type and AC5 Knockout Mice
Adenylyl cyclase type 5 (AC5) was described as major cardiac AC isoform. The knockout of AC5 (AC5KO) exerted cardioprotective… Expand
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2010
2010
Mice lacking adenylyl cyclase type 5 (AC5) show increased ethanol consumption and reduced ethanol sensitivity
RationaleThe adenylyl cyclase (AC)/cAMP system is believed to be a key component in regulating alcohol-drinking behavior. It was… Expand
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Highly Cited
2006
Highly Cited
2006
Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action.
Opioid drugs produce their pharmacological effects by activating inhibitory guanine nucleotide-binding regulatory protein-linked… Expand
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2005
2005
Adenylyl cyclase type V deletion increases basal left ventricular function and reduces left ventricular contractile responsiveness to β–adrenergic stimulation
Abstract We tested the hypothesis that deletion of adenylyl cyclase type V (ACV) would be associated with decreased left… Expand
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2002
2002
A Critical Interplay between Ca2+ Inhibition and Activation by Mg2+ of AC5 Revealed by Mutants and Chimeric Constructs*
Adenylyl cyclase type 5 (AC5) is sensitive to both high and low affinity inhibition by Ca2+. This property provides a sensitive… Expand
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2000
2000
Ca2+, Sr2+, and Ba2+ Identify Distinct Regulatory Sites on Adenylyl Cyclase (AC) Types VI and VIII and Consolidate the Apposition of Capacitative Cation Entry Channels and Ca2+-sensitive ACs*
Ca2+-sensitive adenylyl cyclases may act as early integrators of the two major second messenger-signaling pathways mediated by… Expand
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