adenovirus p53 gene therapy agent

Known as: Ad-p53 vector, Ad-p53, adenovirus p53 construct 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2016
051019962016

Papers overview

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2008
2008
We have identified TNFSF10 (TRAIL) as a p53-transcriptional target gene. There are two p53 DNA-binding sites in the human TNFSF10… (More)
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2004
2004
Treating lung cancer cell lines using low-dose 5-aza-2′-deoxycytidine (DAC) caused an accumulation of procaspase-9 through mRNA… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE Advances in brain tumor biology indicate that transfer of p53 is an alternative therapy for human gliomas. Consequently… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE We designed a prospective single arm Phase II study to evaluate the feasibility and mechanisms of apoptosis induction… (More)
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2002
2002
Therapeutic replacement of the p53 gene using an adenovirus vector (Ad-p53) may be an effective alternative to conventional… (More)
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2000
2000
The infection of recombinant adenovirus expressing wild-type p53 (Ad-p53) to lung cancer cells that harbor mutant p53 genes… (More)
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1999
1999
A high incidence of locoregional failure contributes to the poor overall survival rate of around 50% for patients with squamous… (More)
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1999
1999
In this article, we investigated the effect induced by the reintroduction of wild-type p53 (wt-p53) protein on BCNU sensitivity… (More)
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Highly Cited
1998
Highly Cited
1998
PURPOSE Standard therapies of head and neck squamous cell carcinoma (HNSCC) often cause profound morbidity and have not… (More)
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1998
1998
We investigated the p53 status and the ability of exogenous wildtype (wt) p53 to affect chemosensitivity in three anaplastic… (More)
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