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acyline

National Institutes of Health

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Broader (1)

Oligopeptides

Papers overview

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Highly Cited
2010
Highly Cited
2010
Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus.
Human genetics indicate that kisspeptin and neurokinin B (NKB) signaling are necessary for generating pulsatile LH release and… 
Highly Cited
2009
Highly Cited
2009
Comparison of the effects of peripherally administered kisspeptins
Highly Cited
2007
Highly Cited
2007
Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer.
Androgen deprivation therapy (ADT) remains the primary treatment for advanced prostate cancer. The efficacy of ADT has not been… 
Highly Cited
2007
Highly Cited
2007
Suppression of kisspeptin expression and gonadotropic axis sensitivity following exposure to inhibitory day lengths in female Siberian hamsters
Highly Cited
2006
Highly Cited
2006
Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing…
The purpose of the present study was to further examine the hypothesis that activation of G protein-coupled receptor 54 (GPR54… 
Highly Cited
2006
Highly Cited
2006
Persistent intraprostatic androgen concentrations after medical castration in healthy men.
CONTEXT The impact of serum androgen manipulation on prostate tissue hormone levels in normal men is unknown. Studies of men with… 
Highly Cited
2006
Highly Cited
2006
Effect of medical castration on CD4+ CD25+ T cells, CD8+ T cell IFN-gamma expression, and NK cells: a physiological role for testosterone and/or its metabolites.
The higher prevalence of autoimmune disease among women compared with men suggests that steroids impact immune regulation. To… 
Highly Cited
2005
Highly Cited
2005
Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat
The KiSS-1 gene codes for a family of neuropeptides called kisspeptins which bind to the G-protein-coupled receptor GPR54. To… 
Highly Cited
2004
Highly Cited
2004
A single dose of the potent gonadotropin-releasing hormone antagonist acyline suppresses gonadotropins and testosterone for 2 weeks in healthy young men.
Acyline is a novel GnRH antagonist that reliably inhibits gonadotropins and testosterone (T) levels in men for 48 h after a… 
Highly Cited
2002
Highly Cited
2002
Acyline: the first study in humans of a potent, new gonadotropin-releasing hormone antagonist.
Acyline is a novel GnRH antagonist found in animal studies to be a potent suppressor of circulating gonadotropin and testosterone… 
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