acyl glucuronidation

The modification of an substrate by the conjugation of glucuronic acid to form an acyl-glucuronide (also called an acyl-glucuronoside). [GOC:BHF, GOC… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2017
02419862017

Papers overview

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2014
2014
Probenecid, a widely used uricosuric agent, is mainly metabolized to probenecid acyl glucuronide (PRAG), which is considered a… (More)
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2011
2011
The chemical reactivity of acyl glucuronide (AG) has been thought to be associated with the toxic properties of drugs containing… (More)
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2007
2007
Glucuronidation, which may take place on the phenolic hydroxyl and carboxyl groups, is a major pathway of metabolism for… (More)
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2006
2006
Acetylsalicylic acid (aspirin) is a common nonsteroidal anti-inflammatory drug used for treatment of pain and arthritis. In the… (More)
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Highly Cited
2005
Highly Cited
2005
AIMS To characterize the kinetics of S-naproxen ('naproxen') acyl glucuronidation and desmethylnaproxen acyl and phenolic… (More)
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2003
2003
Compound A [(+)-(5S,6R,7R)-2-isopropylamino-7-[4-methoxy-2-((2R)-3-methoxy-2-methylpropyl)-5-(3,4-methylenedioxyphenyl… (More)
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Highly Cited
2002
Highly Cited
2002
Diclofenac is eliminated predominantly (approximately 50%) as its 4'-hydroxylated metabolite in humans, whereas the acyl… (More)
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2002
2002
Chemically reactive species formed from the metabolism of carboxylic acid-containing compounds have been proposed as mediators of… (More)
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Highly Cited
1993
Highly Cited
1993
In a few patients diclofenac produces mild increases in serum aminotransferase activity and in rare cases may be associated with… (More)
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1992
1992
The pharmacokinetics of diflunisal, a salicylate derivative that undergoes phenolic and acyl glucuronidation as well as sulphate… (More)
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