activation-induced cell death

Secretory tumor necrosis factor-alpha (sTNF-α) is known to mediate activation- induced cell death (AICD). However, the role of… Expand

Of the known genetic factors contributing to Parkinson’s disease (PD), pathogenic leucine rich repeat kinase 2 (LRRK2) is… Expand

Apoptosis is a major mechanism regulating immune tolerance by the elimination of autoreactive T lymphocytes. A failure of… Expand

Hyperactive PI3K signaling and immune deficiency PI3Ks were discovered by Cantley and colleagues in 1985 (1) and have since been… Expand

In this paper, we sought to identify the CD4(+) T-cell dynamics in the course of HIV infection in response to continuous and… Expand

Alzheimer’s disease (AD) is caused by synaptic and neuronal loss in the brain that eventually results in cognitive decline… Expand

In addition to its proinflammatory effects, TNF‐α exhibits immunosuppression. Here, we compared the capacities of transmembrane… Expand

Although amyloid precursor protein (APP) has central roles in Alzheimer's disease, the physiological functions of this protein… Expand

Restimulation of the T‐cell receptor (TCR) in activated T cells induces CD95 (Fas/Apo‐1)‐mediated activation‐induced cell death… Expand

Summary Thousands of studies of ROS and their effects on cellshave been reported. Therefore it is not surprising thatthese… Expand