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acivicin

Known as: L-(alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, (S-(R*,R*))-4,5-Dihydro-alpha-amino-3-chloro-5-isoxazoleacetic Acid, alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid 
A modified amino acid and structural analog of glutamine. Acivicin inhibits glutamine amidotransferases in the purine and pyrimidine biosynthetic… Expand
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
The release of glutathione from astroglial cells was investigated using astroglia-rich primary cultures prepared from the brains… Expand
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Highly Cited
2003
Highly Cited
2003
In tumor cells, the human multidrug resistance protein 1 (MRP1), confers resistance to a broad spectrum of anticancer agents… Expand
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Highly Cited
2003
Highly Cited
2003
Cisplatin, a commonly used chemotherapeutic agent, is nephrotoxic. The mechanism by which cisplatin selectively kills the… Expand
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Highly Cited
2001
Highly Cited
2001
Acivicin [(alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid] was investigated as an inhibitor of the triad… Expand
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Highly Cited
2000
Highly Cited
2000
Multidrug resistance in tumor cells is often associated with reduced drug accumulation resulting from increased expression of the… Expand
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Highly Cited
1999
Highly Cited
1999
The objective of this study was to characterize the behavior induced by the N-methyl-D-aspartate receptor antagonist MK-801… Expand
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Highly Cited
1999
Highly Cited
1999
Deficiency of the antioxidant glutathione in brain appears to be connected with several diseases characterized by neuronal loss… Expand
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Highly Cited
1994
Highly Cited
1994
Cisplatin [cis-dichlorodiammineplatinum(II)] is a widely used chemotherapeutic drug that is toxic to the proximal tubule cells of… Expand
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Highly Cited
1987
Highly Cited
1987
A multidrug resistant variant (H69AR) of the human small cell lung cancer cell line NCI-H69 was obtained by culturing these cells… Expand
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Highly Cited
1983
Highly Cited
1983
Dipyridamole inhibited the incorporation of cytidine, thymidine, uridine, and guanosine in rat hepatoma 3924A cells with 50… Expand
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