acivicin

Known as: L-(alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, (S-(R*,R*))-4,5-Dihydro-alpha-amino-3-chloro-5-isoxazoleacetic Acid, alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid 
A modified amino acid and structural analog of glutamine. Acivicin inhibits glutamine amidotransferases in the purine and pyrimidine biosynthetic… (More)
National Institutes of Health

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Highly Cited
2003
Highly Cited
2003
Cisplatin, a commonly used chemotherapeutic agent, is nephrotoxic. The mechanism by which cisplatin selectively kills the… (More)
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Highly Cited
2000
Highly Cited
2000
Hypoxia-inducible factor-1 (HIF-1) is an essential transcription factor involved in the oxygen-dependent regulation of gene… (More)
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Highly Cited
1999
Highly Cited
1999
Deficiency of the antioxidant glutathione in brain appears to be connected with several diseases characterized by neuronal loss… (More)
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1997
1997
The release of glutathione from astroglial cells was investigated using astroglia-rich primary cultures prepared from the brains… (More)
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1994
1994
Cisplatin [cis-dichlorodiammineplatinum(II)] is a widely used chemotherapeutic drug that is toxic to the proximal tubule cells of… (More)
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1991
1991
Acivicin (AT-125) is a glutamine antagonist with dose-limiting, schedule-dependent CNS toxicity and predictable CSF penetration… (More)
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1988
1988
Pharmacokinetic studies with the amino acid antineoplastic agent, acivicin, were carried out in the Sprague-Dawley rat… (More)
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Highly Cited
1987
Highly Cited
1987
A multidrug resistant variant (H69AR) of the human small cell lung cancer cell line NCI-H69 was obtained by culturing these cells… (More)
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1986
1986
Acivicin (NSC 163501) and dichloroallyl lawsone (NSC 126771) are potent inhibitors of nucleotide biosynthesis with consequent… (More)
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1983
1983
Dipyridamole inhibited the incorporation of cytidine, thymidine, uridine, and guanosine in rat hepatoma 3924A cells with 50… (More)
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