acipimox

Known as: 5-methylpyrazine-2-carboxylic acid 4-oxide, 5-methylpyrazinecarboxylic acid 4-oxide 
A niacin derivative and nicotinic acid analog with activity as a hypolipidemic agent. Acipimox has special application for the treatment of… (More)
National Institutes of Health

Papers overview

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2007
2007
Elevated plasma FFA cause beta-cell lipotoxicity and impair insulin secretion in nondiabetic subjects predisposed to type 2… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Metabolic modulators that enhance myocardial glucose metabolism by inhibiting free fatty acid (FFA) metabolism may… (More)
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Highly Cited
2005
Highly Cited
2005
To investigate the effect of a sustained (7-day) decrease in plasma free fatty acid (FFA) concentrations on insulin action and… (More)
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Highly Cited
2004
Highly Cited
2004
To test the hypothesis that free fatty acids (FFAs) modulate microvascular function and that this contributes to obesity… (More)
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Highly Cited
1999
Highly Cited
1999
Obesity is commonly associated with elevated plasma free fatty acid (FFA) levels, as well as with insulin resistance and… (More)
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Highly Cited
1998
Highly Cited
1998
The objective of the study was to examine the potential differential effect of insulin and acipimox (both of which reduce free… (More)
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1993
1993
This study examines the effect of nicotinic acid (1 g t.d.s.) on serum Lp(a) concentration in a group of patients with type II… (More)
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1993
1993
To examine whether overnight suppression of free fatty acid levels reduces hepatic glucose production, 20 NIDDM patients were… (More)
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1991
1991
Increased nonesterified fatty acid (NEFA) levels may be important in causing insulin resistance in skeletal muscles in patients… (More)
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1980
1980
Acipimox (5-methylpyrazinecarboxylic acid 4-oxide) is a new lipolysis inhibitor that has a distant chemical relationship with… (More)
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