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acetylacetoin reductase (NADPH)

Known as: AACR I 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Purpose: Immunotherapy with ipilimumab improves the survival of patients with metastatic melanoma. Because only around 20% of… 
Highly Cited
2010
Highly Cited
2010
Mutation at the R132 residue of isocitrate dehydrogenase 1 (IDH1), frequently found in gliomas and acute myelogenous leukemia… 
Highly Cited
2010
Highly Cited
2010
Activation of the mammalian target of rapamycin (mTOR) pathway is an important and early event in tobacco carcinogen–induced lung… 
Highly Cited
2010
Highly Cited
2010
The biguanide metformin is widely used for treating diabetes mellitus. We previously showed the chemopreventive effect of… 
Highly Cited
2010
Highly Cited
2010
Purpose: MicroRNAs (miRNA) are short noncoding RNAs that can play critical roles in diverse biological processes. They are… 
Highly Cited
2010
Highly Cited
2010
Purpose: Lung squamous cell carcinoma (SCC) is clinically and genetically heterogeneous, and current diagnostic practices do not… 
Highly Cited
2010
Highly Cited
2010
Conjugation of cytotoxic compounds to antibodies that bind to cancer-specific antigens makes these drugs selective in killing… 
Highly Cited
2010
Highly Cited
2010
Lymphatic vessels play a major role in cancer progression and in postsurgical lymphedema, and several new therapeutic approaches… 
Highly Cited
2010
Highly Cited
2010
Targeted therapeutics hold tremendous promise in inhibiting cancer cell proliferation. However, targeting proteins individually… 
Highly Cited
2010
Highly Cited
2010
Purpose: We conducted a first-in-human phase I study to determine the dose-limiting toxicity (DLT), evaluate the pharmacokinetic…