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The current study demonstrates the process of selecting an optimal structure for a caspase-3-cleavable doxorubicin prodrug that… Expand 目的：观察z-DEVD-fmk（caspase-3抑制剂）对甲基苯丙胺（methamphetamine,MA）依赖大鼠海马组织caspase-3活性及其蛋白表达的影响.方法：选取健康Wistar大鼠40只,随机分为空白对照组、MA依赖组、MA＋ z-DEVD… Expand BACKGROUND
Microvascular hyperpermeability that occurs in hemorrhagic shock and burn trauma is regulated by the apoptotic… Expand The present study has been designed to investigate the effect of selective inhibitors of histone deacetylase and/or N-acetyl-Asp… Expand Live‐cell detection of intracellular enzyme activity requires that substrates are cell‐permeable and that the generated products… Expand BACKGROUND
Celecoxib, a cyclooxygenase-2 inhibitor, has been found to inhibit the proliferation of several kinds of cancer cells… Expand Infections produce significant respiratory muscle weakness, but the mechanisms by which inflammation reduces muscle force remain… Expand Glomerular mesangial cells play an important role in the development of glomerulosclerosis. Mesangial cell apoptosis has been… Expand Abstract.Background: The effect of a caspase-3 inhibitor on retinal degeneration in C3H mice carrying the rd gene, a mutation of… Expand Background—Oxidative stress after ischemia/reperfusion of cardiac allografts leads to cytokine production. Bcl-2, an inhibitor of… Expand