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, L-Cysteine, S-(4-(acetylamino)phenyl)-
, paracetamol cysteine
National Institutes of Health
analogs & derivatives
Semantic Scholar uses AI to extract papers important to this topic.
Simultaneous Determination of Paracetamol and its Metabolites in Rat Serum by HPLC Method and its Application Supplement-Drug Pharmacokinetic Interaction
Corpus ID: 34399025
In this report, we describe a reliable HPLC method for simultaneous estimation of paracetamol and its metabolites in rat serum…
Population pharmacokinetics of intravenous acetaminophen and its metabolites in major surgical patients
Katie H. Owens
Journal of Pharmacokinetics and Pharmacodynamics
Corpus ID: 18047707
Intravenous acetaminophen is a commonly used analgesic following surgery. The aims of this study were to determine the population…
Acetaminophen-induced hepatotoxicity. Analysis of total covalent binding vs. specific binding to cysteine.
Drug metabolism and disposition: the biological…
Corpus ID: 27881997
Acetaminophen-induced hepatotoxicity is believed to be mediated by covalent binding of the reactive metabolite N-acetyl-p…
Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice.
The Journal of pharmacology and experimental…
Corpus ID: 23125705
The revelation that many covalent binding estimates are falsely low due to flawed normalization discloses that protection by N…
Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat.
N. T. Pedersen
Corpus ID: 3298364
Rats were pretreated with phenobarbital to induce hepatic cytochrome P-450. Compared to noninduced rats, a similar relation…
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