abiraterone

Known as: (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol, 17-(3-pyridyl)androsta-5,16-dien-3beta-ol, Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, (3beta)- 
A steroidal compound with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2018
010020019892018

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND Abiraterone acetate plus prednisone significantly improved radiographic progression-free survival compared with… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND The androgen-receptor isoform encoded by splice variant 7 lacks the ligand-binding domain, which is the target of… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Abiraterone acetate, an androgen biosynthesis inhibitor, improves overall survival in patients with metastatic… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Abiraterone acetate improved overall survival in metastatic castration-resistant prostate cancer at a preplanned… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Biosynthesis of extragonadal androgen may contribute to the progression of castration-resistant prostate cancer. We… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE Abiraterone is a potent inhibitor of the steroidogenic enzyme CYP17A1 and suppresses tumor growth in patients with… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Abiraterone acetate is a prodrug of abiraterone, a selective inhibitor of CYP17, the enzyme catalyst for two essential… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Persistence of ligand-mediated androgen receptor signaling has been documented in castration-resistant prostate cancers… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE It has been postulated that castration-resistant prostate cancer (CRPC) commonly remains hormone dependent. Abiraterone… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Studies indicate that castration-resistant prostate cancer (CRPC) remains driven by ligand-dependent androgen receptor… (More)
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