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abiraterone

Known as: (3?)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol, 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol, Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, (3beta)- 
A steroidal compound with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17… Expand
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND Prostate cancer is a heterogeneous disease, but current treatments are not based on molecular stratification. We… Expand
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Highly Cited
2015
Highly Cited
2015
Androgen receptor mutations and amplifications in circulating tumor DNA provide clues to prostate cancer drug resistance… Expand
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Highly Cited
2015
Highly Cited
2015
Prostate cancer resistance to castration occurs because tumours acquire the metabolic capability of converting precursor steroids… Expand
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Highly Cited
2014
Highly Cited
2014
BACKGROUND The androgen-receptor isoform encoded by splice variant 7 lacks the ligand-binding domain, which is the target of… Expand
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Abiraterone, an androgen synthesis inhibitor, has been successfully used in the treatment of castration-resistant… Expand
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Highly Cited
2014
Highly Cited
2014
Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC… Expand
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Highly Cited
2014
Highly Cited
2014
BACKGROUND The new generation anti-androgen enzalutamide and the potent CYP17 inhibitor abiraterone have both demonstrated… Expand
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Highly Cited
2013
Highly Cited
2013
We read with interest the report from Richards and colleagues ([1][1]) on the potential interactions of abiraterone, eplerenone… Expand
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Abiraterone and docetaxel are both approved treatments for men with metastatic castration-resistant prostate cancer… Expand
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Highly Cited
2011
Highly Cited
2011
Purpose: Abiraterone is a potent inhibitor of the steroidogenic enzyme CYP17A1 and suppresses tumor growth in patients with… Expand
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