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ZOFENOPRIL CALCIUM

The calcium salt of zofenopril, a sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, zofenopril… Expand
National Institutes of Health

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zofenopril

Papers overview

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2015
2015
Physicochemical characterization of zofenopril inclusion complex with hydroxypropyl-β-cyclodextrin
Zofenopril calcium (ZOF)is one of the newest angiotensin converting enzyme (ACE) inhibitor, is one of the highly lipophilic… Expand
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2014
2014
Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition.
AIMS Therapeutic use of sulfhydrylated inhibitor S-zofenopril has raised different hypotheses regarding the role played by its… Expand
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2007
2007
Blood pressure control and response rates with zofenopril compared with amlodipine in hypertensive patients
Angiotensin‐converting enzyme inhibitors (ACEIs) and calcium antagonists are today extensively used as first‐line monotherapy as… Expand
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2004
2004
11C-Radiosynthesis and preliminary human evaluation of the disposition of the ACE inhibitor [11C]zofenoprilat.
(4S)-1-[(S)-3-Mercapto-2-methylpropanoyl]-4-phenylthio-L-proline (Zofenoprilat, 2), the active metabolite of the potent ACE… Expand
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2002
2002
Pharmacokinetic and pharmacodynamic comparative study of zofenopril and enalapril in healthy volunteers.
Zofenopril calcium (CAS 81938-43-4) is a new angiotensin converting enzyme (ACE) inhibitor, which in addition to the typical… Expand
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2000
2000
Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry.
Zofenopril is a pro-drug designed to undergo metabolic hydrolysis yielding the active free sulfhydryl compound zofenoprilat… Expand
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1999
1999
Pharmacokinetics and pharmacodynamics of zofenopril in healthy volunteers.
This study was carried out to investigate the pharmacokinetics of zofenopril (CAS 81938-43-4) and zofenoprilat, the behaviour of… Expand
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1994
1994
Temperature, pH and agitation rate as dissolution test discriminators of zofenopril calcium tablets.
Comparative in vitro dissolution studies were performed on several tablet batches of zofenopril calcium, an ACE inhibitor, to… Expand
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Highly Cited
1993
Highly Cited
1993
Evidence of a partial escape of renin-angiotensin-aldosterone blockade in patients with acute myocardial infarction treated with ACE inhibitors.
Angiotensin-converting enzyme (ACE) inhibitors have been designed to block the renin-angiotensin system and can represent an… Expand
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1989
1989
Preclinical pharmacology of zofenopril, an inhibitor of angiotensin I converting enzyme.
Zofenopril calcium (one-half calcium salt) is a prodrug ester analog of captopril whose biological effects are manifested by its… Expand
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