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ZOFENOPRIL CALCIUM

The calcium salt of zofenopril, a sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, zofenopril… (More)
National Institutes of Health

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Topic mentions per year

1989-2017
01219892017

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zofenopril

Related mentions per year

Related mentions per year

1985-2018
19801990200020102020
ZOFENOPRIL CALCIUM
zofenopril

Papers overview

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2014
2014
Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition.
AIMS Therapeutic use of sulfhydrylated inhibitor S-zofenopril has raised different hypotheses regarding the role played by its… (More)
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2007
2007
Blood pressure control and response rates with zofenopril compared with amlodipine in hypertensive patients.
Angiotensin-converting enzyme inhibitors (ACEIs) and calcium antagonists are today extensively used as first-line monotherapy as… (More)
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2004
2004
11C-Radiosynthesis and preliminary human evaluation of the disposition of the ACE inhibitor [11C]zofenoprilat.
(4S)-1-[(S)-3-Mercapto-2-methylpropanoyl]-4-phenylthio-L-proline (Zofenoprilat, 2), the active metabolite of the potent ACE… (More)
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2000
2000
Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry.
Zofenopril is a pro-drug designed to undergo metabolic hydrolysis yielding the active free sulfhydryl compound zofenoprilat… (More)
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Review
1999
Review
1999
Preclinical Profile of Zofenopril: An Angiotensin Converting Enzyme Inhibitor with Peculiar Cardioprotective Properties
The discovery of captopril, the prototype of orally active angiotensin-converting enzyme inhibitors (ACEIs), represented a major… (More)
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1994
1994
Temperature, pH and agitation rate as dissolution test discriminators of zofenopril calcium tablets.
Comparative in vitro dissolution studies were performed on several tablet batches of zofenopril calcium, an ACE inhibitor, to… (More)
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1993
1993
Evidence of a partial escape of renin-angiotensin-aldosterone blockade in patients with acute myocardial infarction treated with ACE inhibitors.
Angiotensin-converting enzyme (ACE) inhibitors have been designed to block the renin-angiotensin system and can represent an… (More)
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1991
1991
Sites of First-Pass Bioactivation (Hydrolysis) of Orally Administered Zofenopril Calcium in Dogs
The relative contribution of the gut, liver, and lungs as sites of first-pass bioactivation (hydrolysis) of the orally… (More)
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1990
1990
Disposition of zofenopril calcium in healthy subjects.
Zofenopril calcium (1) is a prodrug that is hydrolyzed in vivo to the active angiotensin-converting enzyme (ACE) inhibitor SQ 26… (More)
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1989
1989
Preclinical pharmacology of zofenopril, an inhibitor of angiotensin I converting enzyme.
Zofenopril calcium (one-half calcium salt) is a prodrug ester analog of captopril whose biological effects are manifested by its… (More)
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