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ZNF217 wt Allele

Known as: ZABC1, ZNF217, Zinc Finger Protein 217 wt Allele 
Human ZNF217 wild-type allele is located in the vicinity of 20q13.2 and is approximately 16 kb in length. This allele, which encodes zinc finger… Expand
National Institutes of Health

Related topics

Related topics

6 relations
20q13.2Ligand BindingTranscriptional RegulationZNF217 gene
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The critical role of the ZNF217 oncogene in promoting breast cancer metastasis to the bone
Bone metastasis affects >70% of patients with advanced breast cancer. However, the molecular mechanisms underlying this process… Expand
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2016
2016
Knockdown of lncRNA-ATB suppresses autocrine secretion of TGF-β2 by targeting ZNF217 via miR-200c in keloid fibroblasts
Abnormally high activation of transforming growth factor-β (TGF-β) signaling has been demonstrated to be involved in the… Expand
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Highly Cited
2014
Highly Cited
2014
MiR-200c suppresses TGF-β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer.
Resistance to trastuzumab and concomitantly distal metastasis are leading causes of mortality in HER2-positive breast cancers… Expand
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2014
2014
ZNF 217 , a candidate breast cancer oncogene amplified at 20 q 13 , regulates expression of the ErbB 3 receptor tyrosine kinase in breast cancer cells
Understanding the mechanisms underlying ErbB3 over-expression in breast cancer will facilitate the rational design of therapies… Expand
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2010
2010
ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells
Understanding the mechanisms underlying ErbB3 overexpression in breast cancer will facilitate the rational design of therapies to… Expand
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2008
2008
Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex.
The ZNF217 oncoprotein is a constituent of a core transcriptional complex that includes CoREST, histone deacetylase 1/2, lysine… Expand
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2008
2008
The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas.
Ovarian epithelial carcinomas (OECs) frequently exhibit amplifications at the 20q13 locus which is the site of several oncogenes… Expand
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2005
2005
ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction.
Chromosome 20q13.2 is amplified in 20-30% of early-stage breast tumors and is associated with poor prognosis. Detailed mapping of… Expand
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Highly Cited
2003
Highly Cited
2003
Amplification and overexpression of JUNB is associated with primary cutaneous T-cell lymphomas.
Primary cutaneous lymphomas (PCLs) represent a heterogeneous group of extranodal T- and B-cell malignancies. The underlying… Expand
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2000
2000
Differences in 20q13.2 copy number between colorectal cancers with and without liver metastasis.
Frequent gains of 20q have been identified recently in many neoplasias, including breast, bladder, ovarian, pancreatic, and colon… Expand
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