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ZD 6021

Known as: (3-cyano-N-(2-(3,4-dichlorophenyl)-4-(4-(2-(methylsulfinyl)phenyl)piperidino)butyl)-N-methyl)naphthamide, ZD-6021, ZD6021 
 
National Institutes of Health

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2 relations

Broader (2)

PiperidinesSulfoxides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Characterization of species-related differences in the pharmacology of tachykinin NK receptors 1, 2 and 3.
Tachykinin NK receptors (NKRs) differ to a large degree among species with respect to their affinities for small molecule… Expand
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2008
2008
Occurrence and pharmacological characterization of four human tachykinin NK2 receptor variants.
Tachykinin NK(2) receptor antagonists are potentially beneficial in treating various disorders including irritable bowel syndrome… Expand
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2007
2007
Neurokinin 1 receptor antagonists: correlation between in vitro receptor interaction and in vivo efficacy.
We compared the neurokinin 1 receptor (NK(1)R) antagonists aprepitant, CP-99994 [(2S,3S)-3-(2-methoxybenzylamino)-2… Expand
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2007
2007
Molecular cloning, mutations and effects of NK1 receptor antagonists reveal the human-like pharmacology of gerbil NK1 receptors.
The present study investigates the pharmacology of the cloned neurokinin 1 receptor from the gerbil (gNK(1)R), a species claimed… Expand
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2004
2004
Glutamate and tachykinin receptors in central sensitization of withdrawal reflexes in the decerebrated rabbit.
This study assessed the involvement of NMDA and group I metabotropic glutamate receptors, and tachykinin NK1 and NK3 receptors… Expand
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2002
2002
Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity.
Through optimization of compounds based on the dual NK(1)/NK(2) antagonist ZD6021, it was found that alteration of two key… Expand
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2001
2001
Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors.
The tachykinins, substance P, neurokinin A, and neurokinin B, have been implicated in many diseases. The present study evaluated… Expand
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2001
2001
Discovery of novel, orally active dual NK1/NK2 antagonists.
Exploration of the SAR around selective NK2 antagonists, SR48968 and ZD7944, led to the discovery that naphth-1-amide analogues… Expand
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