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ZD 2767

Known as: ZD-2767, ZD2767, ZD2767P 
A phenol mustard glutamate prodrug which induces apoptosis by cross-linking DNA and with potential use in Antibody Directed Enzyme Prodrug Therapy… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
We have designed a targeted systemic suicide gene therapy that combines the advantages of tumor-selective gene expression, using… Expand
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Highly Cited
2005
Highly Cited
2005
PURPOSE Antibody-directed enzyme prodrug therapy (ADEPT) requires highly selective antibody-mediated delivery of enzyme to tumor… Expand
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2004
2004
RIT in “low grade” NHL produces high objective response rates with durable complete responses. The most impressive results… Expand
Highly Cited
2002
Highly Cited
2002
Antibody-directed enzyme prodrug therapy is a targeted therapy in which a prodrug is activated selectively at the tumour site by… Expand
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2002
2002
Cellular determinants of sensitivity to the bifunctional alkylating agent 4-[N,N-bis(2-iodoethyl)amino]phenol (ZD2767D), the… Expand
2001
2001
An antibody-directed enzyme prodrug therapy (ADEPT) system against CEA-positive tumours is currently in phase I clinical trials… Expand
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2001
2001
ZD2767P is a phenol mustard glutamate prodrug which is currently being developed for Antibody Directed Enzyme Prodrug Therapy… Expand
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2000
2000
ZD2767P, a nitrogen mustard glutamate prodrug, is currently being evaluated in Phase 1 clinical trials of antibody directed… Expand
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Highly Cited
1996
Highly Cited
1996
ZD2767 represents an improved version of antibody-directed enzyme prodrug therapy. It consists of a conjugate of the F(ab')2 A5B7… Expand
Highly Cited
1995
Highly Cited
1995
Sixteen novel potential prodrugs derived from phenol or aniline mustards and their 16 corresponding drugs with ring substitution… Expand