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ZD 2767

Known as: ZD-2767, ZD2767, ZD2767P 
A phenol mustard glutamate prodrug which induces apoptosis by cross-linking DNA and with potential use in Antibody Directed Enzyme Prodrug Therapy… Expand
National Institutes of Health

Papers overview

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2007
2007
We have designed a targeted systemic suicide gene therapy that combines the advantages of tumor-selective gene expression, using… Expand
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2005
2005
PURPOSE Antibody-directed enzyme prodrug therapy (ADEPT) requires highly selective antibody-mediated delivery of enzyme to tumor… Expand
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2004
2004
RIT in “low grade” NHL produces high objective response rates with durable complete responses. The most impressive results… Expand
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Highly Cited
2002
Highly Cited
2002
Antibody-directed enzyme prodrug therapy is a targeted therapy in which a prodrug is activated selectively at the tumour site by… Expand
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2002
2002
Cellular determinants of sensitivity to the bifunctional alkylating agent 4-[N,N-bis(2-iodoethyl)amino]phenol (ZD2767D), the… Expand
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2001
2001
An antibody-directed enzyme prodrug therapy (ADEPT) system against CEA-positive tumours is currently in phase I clinical trials… Expand
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2001
2001
ZD2767P is a phenol mustard glutamate prodrug which is currently being developed for Antibody Directed Enzyme Prodrug Therapy… Expand
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1999
1996
1996
ZD2767 represents an improved version of antibody-directed enzyme prodrug therapy. It consists of a conjugate of the F(ab')2 A5B7… Expand
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1995
1995
Sixteen novel potential prodrugs derived from phenol or aniline mustards and their 16 corresponding drugs with ring substitution… Expand
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