Z, Rat Strain

Known as: ZUC-leprfa, ZUCKER 
Derived from a spontaneous mutation in the leptin receptor that appeared in a 13M rat colony bred at the Zucker Laboratory of Comparative Pathology… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Many approaches to automatic sentiment analysis begin with a large lexicon of words marked with their prior polarity (also called… (More)
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Highly Cited
2007
Highly Cited
2007
Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2… (More)
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Highly Cited
2006
Highly Cited
2006
Polycomb group proteins are essential for early development in metazoans, but their contributions to human development are not… (More)
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Highly Cited
2006
Highly Cited
2006
The brain hypothalamus contains certain secreted molecules that are important in regulating feeding behaviour. Here we show that… (More)
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Highly Cited
2004
Highly Cited
2004
In animal models of lipotoxicity, accumulation of triglycerides within cardiomyocytes is associated with contractile dysfunction… (More)
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Highly Cited
2000
Highly Cited
2000
To determine the mechanism of the cardiac dilatation and reduced contractility of obese Zucker Diabetic Fatty rats, myocardial… (More)
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Highly Cited
1998
Highly Cited
1998
Leptin is a hormone that regulates food intake, and its receptor (OB-Rb) is expressed primarily in the hypothalamus. Here, it is… (More)
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Highly Cited
1998
Highly Cited
1998
Troglitazone (CS-045) is one of the thiazolidinediones that activate the peroxisome proliferator-activated receptor gamma… (More)
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Highly Cited
1998
Highly Cited
1998
Like obese humans, Zucker diabetic fatty (ZDF) rats exhibit early beta cell compensation for insulin resistance (4-fold beta cell… (More)
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Highly Cited
1994
Highly Cited
1994
Hyperinsulinemia, loss of glucose-stimulated insulin secretion (GSIS), and peripheral insulin resistance coexist in non-insulin… (More)
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