Semantic Scholar uses AI to extract papers important to this topic.
OPA1 is the major gene responsible for Dominant Optic Atrophy (DOA) and the syndromic form DOA "plus". Over 370 OPA1 mutations… Expand Background: The intrinsically disordered protein α-synuclein, a hallmark of Parkinson disease, is involved in mitochondrial… Expand Throughout the kingdoms of life, transfer RNA (tRNA) undergoes over 100 enzyme-catalyzed, methyl-based modifications. Although a… Expand Alteration of the epigenome is associated with a wide range of human diseases. Therefore, deciphering the pathways that regulate… Expand Certain guanine-rich sequences are capable of forming higher order structures known as G-quadruplexes. Moreover, particular… Expand Yeast self‐perpetuating amyloids (prions) provide a convenient model for studying the cellular control of highly ordered… Expand In yeast, aggregation and toxicity of the expanded polyglutamine fragment of human huntingtin strictly depend on the presence of… Expand The key protein in Alzheimer's disease, the amyloid precursor protein (APP), is a ubiquitously expressed copper-binding… Expand We have expressed dhfr alleles of Plasmodium falciparum in the budding yeast, Saccharomyces cerevisiae, and used this yeast model… Expand Purpose: To identify and characterize the specificity and potency of topoisomerase II-interacting antitumour drugs in an in vivo… Expand