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Yeast Model System

Known as: Yeast Model 
Pathways and other molecular and cellular processes which can be manipulated in yeast, the results of which can be extrapolated to human systems.
National Institutes of Health

Papers overview

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2018
2018
OPA1 is the major gene responsible for Dominant Optic Atrophy (DOA) and the syndromic form DOA "plus". Over 370 OPA1 mutations… Expand
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Highly Cited
2015
Highly Cited
2015
Background: The intrinsically disordered protein α-synuclein, a hallmark of Parkinson disease, is involved in mitochondrial… Expand
Review
2012
Review
2012
Throughout the kingdoms of life, transfer RNA (tRNA) undergoes over 100 enzyme-catalyzed, methyl-based modifications. Although a… Expand
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Review
2008
Review
2008
Alteration of the epigenome is associated with a wide range of human diseases. Therefore, deciphering the pathways that regulate… Expand
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Review
2008
Review
2008
Certain guanine-rich sequences are capable of forming higher order structures known as G-quadruplexes. Moreover, particular… Expand
Review
2007
Review
2007
Yeast self‐perpetuating amyloids (prions) provide a convenient model for studying the cellular control of highly ordered… Expand
Highly Cited
2005
Highly Cited
2005
In yeast, aggregation and toxicity of the expanded polyglutamine fragment of human huntingtin strictly depend on the presence of… Expand
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Highly Cited
2004
Highly Cited
2004
The key protein in Alzheimer's disease, the amyloid precursor protein (APP), is a ubiquitously expressed copper-binding… Expand
2001
2001
We have expressed dhfr alleles of Plasmodium falciparum in the budding yeast, Saccharomyces cerevisiae, and used this yeast model… Expand
1998
1998
Purpose: To identify and characterize the specificity and potency of topoisomerase II-interacting antitumour drugs in an in vivo… Expand
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