YC -1 compound

Known as: Lificiguat, YC-1, YC-1 compound 
 
National Institutes of Health

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2010
2010
INTRODUCTION Trauma can result in the severing of the dental pulp vessels, leading to hypoxia and ultimately to pulp necrosis… (More)
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Highly Cited
2008
Highly Cited
2008
Hypoxia-inducible factor (HIF)-1 plays a key role in tumor promotion by inducing approximately 60 genes required for tumor… (More)
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Highly Cited
2007
Highly Cited
2007
Hypoxia-inducible factor 1 (HIF-1), a transcription factor that is critical for tumor adaptation to microenvironmental stimuli… (More)
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2007
2007
Cerebral microvascular endothelial cells form the anatomical basis of the blood-brain barrier (BBB), and the tight junctions of… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Hypoxia-inducible factor 1 alpha (HIF-1alpha), a component of HIF-1, is expressed in human tumors and renders cells… (More)
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2001
2001
Nitric oxide has been proposed to play an important role in neuronal development. We have previously shown that growth cones from… (More)
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2000
2000
The alpha1- and beta1-subunits of human soluble guanylate cyclase (sGC) were coexpressed in the Sf9 cells/baculovirus system. In… (More)
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1999
1999
Soluble guanylyl cyclase (sGC) is the main receptor for nitric oxide, a messenger molecule with multiple clinical implications… (More)
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Highly Cited
1998
Highly Cited
1998
The signaling molecule nitric oxide (NO) mediates many of its effects by the stimulation of soluble guanylyl cyclase (sGC). The… (More)
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1995
1995
1. Our previous study demonstrated that YC-1, a derivative of benzylindazole, is a novel activator of soluble guanylate cyclase… (More)
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