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XRCC1 protein, human

Known as: X-Ray Repair Cross Complementing Protein 1, X-ray repair complementing defective repair in Chinese hamster cells 1 protein, human, DNA Repair Protein XRCC1 
DNA repair protein XRCC1 (633 aa, ~69 kDa) is encoded by the human XRCC1 gene. This protein is involved in repair of both DNA strand breakage and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
The molecular role of poly (ADP-ribose) polymerase-1 in DNA repair is unclear. Here, we show that the single-strand break repair… Expand
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Highly Cited
2002
Highly Cited
2002
The DNA damage dependence of poly(ADP-ribose) polymerase-2 (PARP-2) activity is suggestive of its implication in genome… Expand
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Highly Cited
2001
Highly Cited
2001
The major human AP endonuclease APE1 (HAP1, APEX, Ref1) initiates the repair of abasic sites generated either spontaneously, from… Expand
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Highly Cited
2001
Highly Cited
2001
XRCC1 protein is required for DNA single-strand break repair and genetic stability but its biochemical role is unknown. Here, we… Expand
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Highly Cited
2000
Highly Cited
2000
Polymorphisms in several DNA repair genes have recently been identified, but little is known about their phenotypic significance… Expand
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Highly Cited
1999
Highly Cited
1999
Hereditary genetic defects in DNA repair lead to increased risk of cancer. Polymorphisms in several DNA repair genes have been… Expand
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Highly Cited
1998
Highly Cited
1998
Poly(ADP-ribose) polymerase (PARP; EC 2.4.2.30) is a zinc-finger DNA-binding protein that detects and signals DNA strand breaks… Expand
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Highly Cited
1996
Highly Cited
1996
Repair of a uracil-guanine base pair in DNA has been reconstituted with the recombinant human proteins uracil-DNA glycosylase… Expand
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Highly Cited
1996
Highly Cited
1996
The DNA repair proteins XRCC1 and DNA ligase III are physically associated in human cells and directly interact in vitro and in… Expand
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Highly Cited
1994
Highly Cited
1994
XRCC1, the human gene that fully corrects the Chinese hamster ovary DNA repair mutant EM9, encodes a protein involved in the… Expand
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