XRCC1 protein, human

Known as: X-Ray Repair Cross Complementing Protein 1, X-ray repair complementing defective repair in Chinese hamster cells 1 protein, human, DNA Repair Protein XRCC1 
DNA repair protein XRCC1 (633 aa, ~69 kDa) is encoded by the human XRCC1 gene. This protein is involved in repair of both DNA strand breakage and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2017
05010019892017

Papers overview

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Highly Cited
2003
Highly Cited
2003
The molecular role of poly (ADP-ribose) polymerase-1 in DNA repair is unclear. Here, we show that the single-strand break repair… (More)
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Highly Cited
2001
Highly Cited
2001
The major human AP endonuclease APE1 (HAP1, APEX, Ref1) initiates the repair of abasic sites generated either spontaneously, from… (More)
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Highly Cited
2001
Highly Cited
2001
XRCC1 protein is required for DNA single-strand break repair and genetic stability but its biochemical role is unknown. Here, we… (More)
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Highly Cited
2001
Highly Cited
2001
X-ray repair cross complementing group 1 (XRCC1) encodes a protein involved in base excision repair. We examined the association… (More)
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Highly Cited
2000
Highly Cited
2000
Polymorphisms in several DNA repair genes have recently been identified, but little is known about their phenotypic significance… (More)
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Highly Cited
1998
Highly Cited
1998
Poly(ADP-ribose) polymerase (PARP; EC 2.4.2.30) is a zinc-finger DNA-binding protein that detects and signals DNA strand breaks… (More)
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Highly Cited
1996
Highly Cited
1996
Repair of a uracil-guanine base pair in DNA has been reconstituted with the recombinant human proteins uracil-DNA glycosylase… (More)
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Highly Cited
1996
Highly Cited
1996
The DNA repair proteins XRCC1 and DNA ligase III are physically associated in human cells and directly interact in vitro and in… (More)
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Highly Cited
1994
Highly Cited
1994
XRCC1, the human gene that fully corrects the Chinese hamster ovary DNA repair mutant EM9, encodes a protein involved in the… (More)
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Highly Cited
1990
Highly Cited
1990
We describe the cloning and function of the human XRCC1 gene, which is the first mammalian gene isolated that affects cellular… (More)
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