XPO1 wt Allele

Known as: CRM1, exp1, Exportin-1 (Required For Chromosome Region Maintenance) Gene 
Human XPO1 wild-type allele is located in the vicinity of 2p15 and is approximately 61 kb in length. This allele, which encodes exportin-1 protein… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1968-2018
010203019682018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Treating cancer through inhibition of nuclear export is one of the best examples of basic research translation into clinical… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
Review
2015
Review
2015
Nucleocytoplasmic trafficking of proteins/RNAs is essential to normal cellular function. Indeed, accumulating evidence suggests… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The fifth component of the COP9 signalosome complex, Jab1/CSN5, directly binds to and induces specific down-regulation of the… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
GSK-3beta-dependent phosphorylation of cyclin D1 at Thr-286 promotes the nuclear-to-cytoplasmic redistribution of cyclin D1… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1999
Highly Cited
1999
The cellular target of leptomycin B (LMB), a nuclear export inhibitor, has been identified as CRM1 (exportin 1), an… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Leptomycin B (LMB) is a Streptomyces metabolite that inhibits nuclear export of the human immunodeficiency virus type 1… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
CRM1 is distantly related to receptors that mediate nuclear protein import and was previously shown to interact with the nuclear… (More)
  • figure 2
  • figure 4
  • figure 6
  • figure 5
  • figure 7
Is this relevant?
Highly Cited
1997
Highly Cited
1997
The discovery of nuclear export signals (NESs) in a number of proteins revealed the occurrence of signal-dependent transport of… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Nuclear protein export is mediated by nuclear export signals (NESs), but the mechanisms governing this transport process are not… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 6
  • figure 5
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Chromosome maintenance region 1 (CRM1), a protein that shares sequence similarities with the karyopherin beta family of proteins… (More)
Is this relevant?