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Warburg Effect

This effect refers to the high cellular levels of lactic acid in tumor cells, and is named after Otto Warburg who worked on photosynthesis. Tumor… Expand
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Targeted cancer therapies that use genetics are successful, but principles for selectively targeting tumor metabolism that is… Expand
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2017
2017
Background/Aims: The enhanced proliferation of pulmonary arterial smooth muscle cells (PASMCs) is a central pathological… Expand
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Review
2016
Review
2016
  • A. Otto
  • Cancer & metabolism
  • 2016
  • Corpus ID: 23503461
Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence… Expand
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Review
2016
Review
2016
  • S. Devic
  • Journal of Cancer
  • 2016
  • Corpus ID: 1881067
Ever since its discovery (1924) the Warburg effect (aerobic glycolysis) remains an unresolved puzzle: why the aggressive cancer… Expand
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2016
2016
BackgroundTrastuzumab, a humanized antibody targeting HER2, exhibits remarkable therapeutic efficacy against HER2-positive… Expand
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Highly Cited
2015
Highly Cited
2015
Tumor chemoresistance is associated with high aerobic glycolysis rates and reduced oxidative phosphorylation, a phenomenon called… Expand
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2015
2015
Epithelial ovarian cancer (EOC) is the most lethal and aggressive gynecological malignancy, and abnormal cellular metabolism… Expand
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2014
2014
Background: Current understanding of mitochondrial PDH inhibition involves Ser-293 phosphorylation that impedes active site… Expand
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Highly Cited
2013
Highly Cited
2013
Background: Cancer cells rely on energy metabolism that requires increased glucose uptake and constitutive NF-κB activity for… Expand
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Highly Cited
2012
Highly Cited
2012
Glucose metabolism in preimplantation embryos has traditionally been viewed from a somatic cell viewpoint. Here, we show that… Expand
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