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Warburg Effect

This effect refers to the high cellular levels of lactic acid in tumor cells, and is named after Otto Warburg who worked on photosynthesis. Tumor… Expand
National Institutes of Health

Related topics

Related topics

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Glycolysis

Papers overview

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Highly Cited
2017
Highly Cited
2017
A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.
Targeted cancer therapies that use genetics are successful, but principles for selectively targeting tumor metabolism that is… Expand
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2017
2017
PDGF Promotes the Warburg Effect in Pulmonary Arterial Smooth Muscle Cells via Activation of the PI3K/AKT/mTOR/HIF-1α Signaling Pathway
Background/Aims: The enhanced proliferation of pulmonary arterial smooth muscle cells (PASMCs) is a central pathological… Expand
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Review
2016
Review
2016
Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism
  • A. Otto
  • Cancer & metabolism
  • 2016
    • Corpus ID: 23503461
Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence… Expand
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Review
2016
Review
2016
Warburg Effect - a Consequence or the Cause of Carcinogenesis?
  • S. Devic
  • Journal of Cancer
  • 2016
    • Corpus ID: 1881067
Ever since its discovery (1924) the Warburg effect (aerobic glycolysis) remains an unresolved puzzle: why the aggressive cancer… Expand
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2016
2016
A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway
BackgroundTrastuzumab, a humanized antibody targeting HER2, exhibits remarkable therapeutic efficacy against HER2-positive… Expand
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Highly Cited
2015
Highly Cited
2015
Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
Tumor chemoresistance is associated with high aerobic glycolysis rates and reduced oxidative phosphorylation, a phenomenon called… Expand
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2015
2015
MicroRNA-29B (mir-29b) regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
Epithelial ovarian cancer (EOC) is the most lethal and aggressive gynecological malignancy, and abnormal cellular metabolism… Expand
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2014
2014
Tyr-301 Phosphorylation Inhibits Pyruvate Dehydrogenase by Blocking Substrate Binding and Promotes the Warburg Effect*
Background: Current understanding of mitochondrial PDH inhibition involves Ser-293 phosphorylation that impedes active site… Expand
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Highly Cited
2013
Highly Cited
2013
Hyper-O-GlcNAcylation Is Anti-apoptotic and Maintains Constitutive NF-κB Activity in Pancreatic Cancer Cells*
Background: Cancer cells rely on energy metabolism that requires increased glucose uptake and constitutive NF-κB activity for… Expand
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Highly Cited
2012
Highly Cited
2012
Glycolysis in preimplantation development is partially controlled by the Warburg Effect.
Glucose metabolism in preimplantation embryos has traditionally been viewed from a somatic cell viewpoint. Here, we show that… Expand
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