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Warburg Effect

This effect refers to the high cellular levels of lactic acid in tumor cells, and is named after Otto Warburg who worked on photosynthesis. Tumor… 
National Institutes of Health

Related topics

Related topics

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Glycolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
The Warburg effect: 80 years on
Influential research by Warburg and Cori in the 1920s ignited interest in how cancer cells' energy generation is different from… 
Review
2016
Review
2016
Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism
  • A. Otto
  • Cancer & metabolism
  • 2016
  • Corpus ID: 23503461
Virtually everyone working in cancer research is familiar with the “Warburg effect”, i.e., anaerobic glycolysis in the presence… 
Review
2016
Review
2016
The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate
This review summarizes the current state of knowledge about the metabolism of cancer cells, especially with respect to the… 
Highly Cited
2016
Highly Cited
2016
A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway
BackgroundTrastuzumab, a humanized antibody targeting HER2, exhibits remarkable therapeutic efficacy against HER2-positive… 
Review
2016
Review
2016
Warburg Effect - a Consequence or the Cause of Carcinogenesis?
  • S. Devic
  • Journal of Cancer
  • 2016
  • Corpus ID: 1881067
Ever since its discovery (1924) the Warburg effect (aerobic glycolysis) remains an unresolved puzzle: why the aggressive cancer… 
Highly Cited
2015
Highly Cited
2015
Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
Tumor chemoresistance is associated with high aerobic glycolysis rates and reduced oxidative phosphorylation, a phenomenon called… 
Review
2014
Review
2014
2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy.
Highly Cited
2014
Highly Cited
2014
CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism.
Review
2013
Review
2013
The Warburg effect then and now: From cancer to inflammatory diseases
Inflammatory immune cells, when activated, display much the same metabolic profile as a glycolytic tumor cell. This involves a… 
Review
2011
Review
2011
Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review
Cancer is a metabolic disease and the solution of two metabolic equations: to produce energy with limited resources and to… 
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