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WZ4002

 
National Institutes of Health

Papers overview

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2016
2016
Mutant-selective, 3rd-generation EGFR-TKIs were recently developed to control lung cancer cells harboring T790M-mediated… Expand
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Highly Cited
2015
Highly Cited
2015
UNLABELLED Irreversible pyrimidine-based EGFR inhibitors, including WZ4002, selectively inhibit both EGFR-activating and EGFR… Expand
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Highly Cited
2015
Highly Cited
2015
Purpose: Mutant selective irreversible pyrimidine-based EGFR kinase inhibitors, including WZ4002, CO-1686, and AZD9291, are… Expand
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2015
2015
To overcome T790M-mediated acquired resistance of lung cancer cells to epidermal growth factor receptor tyrosine kinase… Expand
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2014
2014
Approximately 4 to 15% of lung adenocarcinomas harbor a genomic rearrangement in the anaplastic lymphoma kinase gene (ALK) that… Expand
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Highly Cited
2013
Highly Cited
2013
The clinical efficacy of EGF receptor (EGFR) kinase inhibitors gefitinib and erlotinib is limited by the development of drug… Expand
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2013
2013
Purpose Although EGF receptor tyrosine kinase inhibitors (EGFR-TKI) have shown dramatic effects against EGFR mutant lung cancer… Expand
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Highly Cited
2012
Highly Cited
2012
The clinical efficacy of epidermal growth factor receptor (EGFR) kinase inhibitors is limited by the development of drug… Expand
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Highly Cited
2012
Highly Cited
2012
Although the EGF receptor tyrosine kinase inhibitors (EGFR-TKI) erlotinib and gefitinib have shown dramatic effects against EGFR… Expand
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2012
2012
Src has a role in the anoikis resistance in lung adenocarcinomas. We focused on two epidermal growth factor receptor (EGFR… Expand
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