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WR 238605
Known as:
WR-238605
National Institutes of Health
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Related topics
1 relation
Broader (1)
tafenoquine
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Simultaneous Modeling of the Pharmacokinetics and Methemoglobin Pharmacodynamics of an 8-Aminoquinoline Candidate Antimalarial (WR 238605)
R. Brueckner
,
L. Fleckenstein
Pharmaceutical Research
2004
Corpus ID: 24622790
Methemoglobin (MHb) formation can be a clinically significant and dose-limiting side effect of 8-aminoquinoline antimalarials…
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2003
2003
Transmission-blocking activity of tafenoquine (WR-238605) and artelinic acid against naturally circulating strains of Plasmodium vivax in Thailand.
Narong Ponsa
,
J. Sattabongkot
,
P. Kittayapong
,
N. Eikarat
,
R. Coleman
American Journal of Tropical Medicine and Hygiene
2003
Corpus ID: 33028007
The sporontocidal activity of tafenoquine (WR-238605) and artelinic acid was determined against naturally circulating isolates of…
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2003
2003
Blood schizontocidal activity of WR 238605 (Tafenoquine) against Plasmodium cynomolgi and Plasmodium fragile infections in rhesus monkeys.
S. Puri
,
G. P. Dutta
Acta Tropica
2003
Corpus ID: 43605384
Highly Cited
2001
Highly Cited
2001
A new primaquine analogue, tafenoquine (WR 238605), for prophylaxis against Plasmodium falciparum malaria.
G. Shanks
,
A. Oloo
,
+5 authors
R. Brueckner
Clinical Infectious Diseases
2001
Corpus ID: 7494810
We tested tafenoquine (WR 238605), a new long-acting 8-aminoquinoline, for its ability to prevent malaria in an area that is…
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Highly Cited
1999
Highly Cited
1999
Randomized dose-ranging study of the safety and efficacy of WR 238605 (Tafenoquine) in the prevention of relapse of Plasmodium vivax malaria in Thailand.
D. Walsh
,
S. Looareesuwan
,
+11 authors
R. Brueckner
Journal of Infectious Diseases
1999
Corpus ID: 34043161
WR 238605 is an 8-aminoquinoline developed for the radical cure of Plasmodium vivax. Forty-four P. vivax-infected patients were…
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Highly Cited
1998
Highly Cited
1998
First-time-in-humans safety and pharmacokinetics of WR 238605, a new antimalarial.
R. Brueckner
,
K. Lasseter
,
E. Lin
,
B. Schuster
American Journal of Tropical Medicine and Hygiene
1998
Corpus ID: 29336489
WR 238605 is an 8-aminoquinoline drug currently under development for prophylaxis and treatment of malaria. Preclinical studies…
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Highly Cited
1998
Highly Cited
1998
Prophylaxis of Plasmodium falciparumInfection in a Human Challenge Model with WR 238605, a New 8-Aminoquinoline Antimalarial
R. Brueckner
,
T. Coster
,
D. Wesche
,
M. Shmuklarsky
,
B. Schuster
Antimicrobial Agents and Chemotherapy
1998
Corpus ID: 43341967
ABSTRACT The prophylactic efficacy of WR 238605, a primaquine analog, was studied with a human Plasmodium falciparum challenge…
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Highly Cited
1997
Highly Cited
1997
WR 238605, chloroquine, and their combinations as blood schizonticides against a chloroquine-resistant strain of Plasmodium vivax in Aotus monkeys.
N. Obaldía
,
R. Rossan
,
+4 authors
G. Shanks
American Journal of Tropical Medicine and Hygiene
1997
Corpus ID: 7346287
The compound WR 238605 is a primaquine analog being developed by the U.S. Army as an antimalarial drug. Currently, there is no…
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1995
1995
Metabolism of a candidate 8-aminoquinoline antimalarial agent, WR 238605, by rat liver microsomes.
O. R. Idowu
,
J. Peggins
,
T. Brewer
,
C. Kelley
Drug Metabolism And Disposition
1995
Corpus ID: 26043044
The in vitro metabolism of the 8-aminoquinoline, 8-(4-amino-1- methylbutylamino-2,6-dimethoxy-4-methyl-5-(3-trifluromethyl…
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1990
1990
Sporontocidal activity of the antimalarial WR-238605 against Plasmodium berghei ANKA in Anopheles stephensi.
R. Coleman
American Journal of Tropical Medicine and Hygiene
1990
Corpus ID: 36400613
The influence of WR-238605 (8-[(4-amino-1-methyl-butyl) amino]-2,6-dimethoxy-4-methyl-5-[3-tri-fluoromethylphenoxyl] quinoline…
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