WEE1 gene

Known as: WEE1, S. POMBE, HOMOLOG OF, WEE1 Homolog (S. pombe) Gene, WEE1A 
This gene plays a role in cell cycle regulation.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Inhibition of the protein kinase WEE1 synergizes with chemotherapy in preclinical models and WEE1 inhibitors are being explored… (More)
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Highly Cited
2011
Highly Cited
2011
WEE1 kinase is a key molecule in maintaining G₂-cell-cycle checkpoint arrest for premitotic DNA repair. Whereas normal cells… (More)
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Highly Cited
2010
Highly Cited
2010
Kinases execute pivotal cellular functions and are therefore widely investigated as potential targets in anticancer treatment… (More)
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Highly Cited
2007
Highly Cited
2007
Movement through the cell cycle is controlled by the temporally and spatially ordered activation of cyclin-dependent kinases… (More)
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Highly Cited
2007
Highly Cited
2007
Upon the incidence of DNA stress, the ataxia telangiectasia-mutated (ATM) and Rad3-related (ATR) signaling kinases activate a… (More)
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Highly Cited
2005
Highly Cited
2005
At the onset of M phase, the activity of somatic Wee1 (Wee1A), the inhibitory kinase for cyclin-dependent kinase (CDK), is down… (More)
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Highly Cited
2004
Highly Cited
2004
Wee1, the Cdc2 inhibitory kinase, needs to be down-regulated at the onset of mitosis to ensure rapid activation of Cdc2… (More)
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2002
2002
Little is known about the genes that regulate cyclinB–Cdc2 complexes at the G2/M transition of the plant cell cycle although in… (More)
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Highly Cited
1995
Highly Cited
1995
WEE1 kinase negatively regulates entry into mitosis by catalyzing the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase… (More)
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Highly Cited
1992
Highly Cited
1992
Entry into mitosis in Schizosaccharomyces pombe is negatively regulated by the wee1+ gene, which encodes a protein kinase with… (More)
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