WEE1 gene

Inhibition of the protein kinase WEE1 synergizes with chemotherapy in preclinical models and WEE1 inhibitors are being explored… (More)

WEE1 kinase is a key molecule in maintaining G₂-cell-cycle checkpoint arrest for premitotic DNA repair. Whereas normal cells… (More)

Kinases execute pivotal cellular functions and are therefore widely investigated as potential targets in anticancer treatment… (More)

Movement through the cell cycle is controlled by the temporally and spatially ordered activation of cyclin-dependent kinases… (More)

Upon the incidence of DNA stress, the ataxia telangiectasia-mutated (ATM) and Rad3-related (ATR) signaling kinases activate a… (More)

At the onset of M phase, the activity of somatic Wee1 (Wee1A), the inhibitory kinase for cyclin-dependent kinase (CDK), is down… (More)

Wee1, the Cdc2 inhibitory kinase, needs to be down-regulated at the onset of mitosis to ensure rapid activation of Cdc2… (More)

Little is known about the genes that regulate cyclinB–Cdc2 complexes at the G2/M transition of the plant cell cycle although in… (More)

WEE1 kinase negatively regulates entry into mitosis by catalyzing the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase… (More)

Entry into mitosis in Schizosaccharomyces pombe is negatively regulated by the wee1+ gene, which encodes a protein kinase with… (More)