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Valacyclovir hydrochloride

Known as: L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanine Hydrochloride, valacyclovir hcl 
The hydrochloride salt of valacyclovir. Valacyclovir is an acyclovir prodrug that, after metabolization, inhibits viral DNA replication. It is used… Expand
National Institutes of Health

Papers overview

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2013
2013
  • B. Yang, David E Smith
  • Drug Metabolism and Disposition
  • 2013
  • Corpus ID: 1594808
The purpose of this study was to quantitatively determine the contribution of PepT1 [peptide transporter 1 (SLC15A1)] to the… Expand
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Highly Cited
2006
Highly Cited
2006
The absolute bioavailability of the prodrug valacyclovir, the l-valyl ester of acyclovir, after oral administration is… Expand
2004
2004
It has previously been shown that the prodrug Glu(acyclovir)-Sar has a high affinity for PEPT1 in Caco-2 cells. However, affinity… Expand
Highly Cited
2003
Highly Cited
2003
Idiopathic facial paralysis, or Bell's palsy, shows a nonepidemic pattern that might indicate reactivation of a latent… Expand
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2002
2002
L-Valacyclovir, a prodrug of acyclovir, is a substrate for the peptide transporter (PepT1) in the intestinal mucosa, which… Expand
Highly Cited
2000
Highly Cited
2000
OBJECTIVE To compare the efficacy and safety of valacyclovir hydrochloride and famciclovir for the treatment of herpes zoster… Expand
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2000
2000
The purpose of this study was to develop and characterize a functional air-interfaced primary culture of rabbit conjunctival… Expand
1999
1999
OBJECTIVE To document the frequency of genital herpes recurrences in men and women with histories of recurrent genital herpes… Expand
1999
1999
The stability of valacyclovir hydrochloride in three commonly used syrups was studied. Triplicate suspensions of valacyclovir… Expand
Highly Cited
1998
Highly Cited
1998
Objective To compare valacyclovir hydrochloride with acyclovir in the treatment of recurrent genital herpes infection. Design A… Expand
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