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VU0238429

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Simultaneous activation of mGlu2 and muscarinic receptors reverses MK-801-induced cognitive decline in rodents
The activity of an allosteric agonist of muscarinic M1 receptor, VU0357017, and a positive allosteric modulator (PAM) of M5… Expand
2019
2019
Simultaneous activation of muscarinic and GABAB receptors as a bidirectional target for novel antipsychotics
Abstract Recent preclinical studies point to muscarinic and GABAB receptors as novel therapeutic targets for the treatment of… Expand
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2013
2013
Muscarinic receptor M3 mediates human gallbladder contraction through voltage-gated Ca2+ channels and Rho kinase
Abstract Objective. Muscarinic receptors mediate contraction of the human gallbladder through unclear receptor subtypes. The aim… Expand
2013
2013
Figure 7, ACh fold shift determinations for ML326 (VU0467903) and ML129 (VU0238429), at 30 μM, on the rM5 receptor
2010
2010
Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.
This Letter describes a chemical lead optimization campaign directed at VU0238429, the first M(5)-preferring positive allosteric… Expand
2010
2010
Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators.
This Letter describes a chemical lead optimization campaign directed at VU0238429, the first M(5)-preferring positive allosteric… Expand
Highly Cited
2009
Highly Cited
2009
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.
This report describes the discovery and initial characterization of the first positive allosteric modulator of muscarinic… Expand
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