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VU0238429

 
National Institutes of Health

Papers overview

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Review
2020
Review
2020
Simultaneous activation of mGlu2 and muscarinic receptors reverses MK-801-induced cognitive decline in rodents
The activity of an allosteric agonist of muscarinic M1 receptor, VU0357017, and a positive allosteric modulator (PAM) of M5… Expand
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2019
2019
Simultaneous activation of muscarinic and GABAB receptors as a bidirectional target for novel antipsychotics
Abstract Recent preclinical studies point to muscarinic and GABAB receptors as novel therapeutic targets for the treatment of… Expand
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2013
2013
Muscarinic receptor M3 mediates human gallbladder contraction through voltage-gated Ca2+ channels and Rho kinase
Abstract Objective. Muscarinic receptors mediate contraction of the human gallbladder through unclear receptor subtypes. The aim… Expand
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2013
2013
Figure 7, ACh fold shift determinations for ML326 (VU0467903) and ML129 (VU0238429), at 30 μM, on the rM5 receptor
 
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2010
2010
Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.
This Letter describes a chemical lead optimization campaign directed at VU0238429, the first M(5)-preferring positive allosteric… Expand
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2010
2010
Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators.
This Letter describes a chemical lead optimization campaign directed at VU0238429, the first M(5)-preferring positive allosteric… Expand
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Highly Cited
2009
Highly Cited
2009
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.
This report describes the discovery and initial characterization of the first positive allosteric modulator of muscarinic… Expand
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