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VHL protein, human

Known as: von Hippel-Lindau syndrome protein, human, pVHL, von Hippel Lindau Tumor Supressor Protein 
Von Hippel-Lindau disease tumor suppressor (213 aa, ~24 kDa) is encoded by the human VHL gene. This protein plays a role in protein ubiquitination… 
National Institutes of Health

Related topics

Related topics

13 relations
Angiogenesis PathwayBrainGenes, RegulatorHypoxia-Inducible Factor Pathway

Broader (2)

Nuclear ProteinsVon Hippel-Lindau Tumor Suppressor Protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
HIF 2 a-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma
Targeted therapy against VEGF and mTOR pathways has been established as the standard-of-care for metastatic clear cell renal cell… 
2016
2016
Formation of Renal Cysts and Tumors in Vhl / Trp 53-De fi cient Mice Requires HIF 1 a and HIF 2 a
  • 2016
  • Corpus ID: 395185
The von Hippel–Lindau (VHL) tumor suppressor gene is inactivated in the majority of clear cell renal cell carcinomas (ccRCC), but… 
Review
2014
Review
2014
von Hippel-Lindau Disease-Associated Pheochromocytoma : Epidemiology , Clinical Characteristics , and Screening and Surveillance Protocols in Japan
von Hippel-Lindau (VHL) disease is an autosomal dominantly inherited syndrome characterized by a predisposition to various… 
2013
2013
Up-Regulation of pVHL along with Down-Regulation of HIF-1α by NDRG2 Expression Attenuates Proliferation and Invasion in Renal Cancer Cells
The majority of renal cell carcinomas (RCCs) are characterized by loss of function of the tumor suppressor gene von Hippel Lindau… 
2013
2013
HEMATOPOIESIS AND STEM CELLS HIF prolyl hydroxylase 2 ( PHD 2 ) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress
Hematopoietic stem cells (HSCs) are responsible for the continuous production of all blood cell lineages throughout the life of… 
2011
2011
Reduced expression of von Hippel-Lindau protein correlates with decreased apoptosis and high chondrosarcoma grade.
BACKGROUND Mutations and loss of the von Hippel-Lindau (VHL) tumor suppressor gene are associated with most renal cancers as well… 
2007
2007
THE VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN AND KIDNEY CANCER
Inactivation of the von Hippel-Lindau tumor suppressor gene (VHL) plays a causal role in the de- velopment of hereditary (von… 
2006
2006
NovelThioredoxin Inhibitors Paradoxically Increase Hypoxia-Inducible Factor-A Expression but Decrease Functional Transcriptional Activity , DNABinding , and Degradation
Purpose:Hypoxia-inducible factor-a (HIF-a) is a transcription factor that regulates the response to hypoxia. HIF-a protein is… 
2003
2003
pVHL-independent ubiquitination of HIF1alpha and its stabilization by cobalt ion.
Recent studies have shown that hypoxia-inducible factor1alpha (HIF1alpha) is ubiquitinated by an E3-ligase complex containing von… 
2001
2001
Tumor Growth and Invasion Hippel-Lindau Gene Product Is Sufficient to Inhibit Renal-domain of von β 123 Amino Acid Sequence of the − The 104 Updated
The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in patients with VHL disease and in the majority of patients with…