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VAV1 protein, human

Known as: VAV1 Protein, VAV1 Gene Product, vav 1 oncogene portein, human 
VAV1 protein is a proto-oncogene product with features of a transcription factor, including an N-terminal acidic region, a proline-rich region, and… 
National Institutes of Health

Related topics

Related topics

4 relations
Signal TransductionSignaling Pathway GeneVAV1 gene

Broader (1)

proto-oncogene protein vav

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Vav-family proteins in T-cell signalling.
Highly Cited
2003
Highly Cited
2003
Vav1 Dephosphorylation by the Tyrosine Phosphatase SHP-1 as a Mechanism for Inhibition of Cellular Cytotoxicity
ABSTRACT Here, we present data suggesting a novel mechanism for regulation of natural killer (NK) cell cytotoxicity through… 
Review
2002
Review
2002
VAV proteins as signal integrators for multi-subunit immune-recognition receptors
In recent years, substantial progress has been made towards the identification of intracellular signalling molecules that couple… 
Highly Cited
2000
Highly Cited
2000
Vav2 Is an Activator of Cdc42, Rac1, and RhoA*
Vav and Vav2 are members of the Dbl family of proteins that act as guanine nucleotide exchange factors (GEFs) for Rho family… 
Highly Cited
1999
Highly Cited
1999
The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways.
Vav is a GTP/GDP exchange factor (GEF) for members of the Rho-family of GTPases that is rapidly tyrosine-phosphorylated after… 
Highly Cited
1998
Highly Cited
1998
Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
Highly Cited
1998
Highly Cited
1998
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor
Highly Cited
1997
Highly Cited
1997
A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes.
Highly Cited
1996
Highly Cited
1996
Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation.
Highly Cited
1995
Highly Cited
1995
Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes
DURING lymphocyte development, cellular proliferation and posi-tive and negative selection events ensure the production of T and… 
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