V(D)J recombination activating protein 2

Known as: RAG-2 protein, recombination activating gene 2 protein, RAG-2 
V(D)J recombination-activating protein 2 (527 aa, ~59 kDa) is encoded by the human RAG2 gene. This protein plays a role in the mediation of V-D-J… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2016
02419922016

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2011
2011
V(D)J gene segment recombination is linked to the cell cycle by the periodic phosphorylation and destruction of the RAG-2 protein… (More)
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Highly Cited
2007
Highly Cited
2007
V(D)J recombination is initiated by the recombination activating gene (RAG) proteins RAG-1 and RAG-2. The ability of antigen… (More)
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2000
2000
The majority of Atm-deficient mice die of malignant thymic lymphoma by 4-5 mo of age. Cytogenetic abnormalities in these tumors… (More)
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1999
1999
V(D)J recombination occurs at recombination signal sequences (RSSs) containing conserved heptamer and nonamer elements. RAG-1 and… (More)
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Highly Cited
1996
Highly Cited
1996
Several lines of evidence indicate that antibody responses to T-dependent antigens require complement receptors expressed on… (More)
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Highly Cited
1996
Highly Cited
1996
The proteins RAG-1 and RAG-2 are essential for initiation of V(D)J recombination. In dividing cells, RAG-2 accumulates during G1… (More)
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Highly Cited
1994
Highly Cited
1994
The antigen receptors of B and T lymphocytes are encoded in multiple germ-line DNA segments that are joined during lymphocyte… (More)
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1994
1994
The recombinase activating genes RAG-1 and RAG-2 operate together to activate V(D)J recombination, and thus play an essential… (More)
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1993
1993
Antigen receptor genes are assembled by site-specific DNA rearrangement. The recombination activator genes RAG-1 and RAG-2 are… (More)
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1993
1993
The primary repertoire of B and T cells is established by V(D)J recombination. Two closely linked genes, RAG-1 and RAG-2, are… (More)
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