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V(D)J recombination activating protein 2

Known as: RAG-2 protein, recombination activating gene 2 protein, RAG-2 
V(D)J recombination-activating protein 2 (527 aa, ~59 kDa) is encoded by the human RAG2 gene. This protein plays a role in the mediation of V-D-J… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Regulated expression of the recombinase RAG-1 and RAG-2 proteins is necessary for generating the vast repertoire of antigen… Expand
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Highly Cited
2001
Highly Cited
2001
Mice containing livers repopulated with human hepatocytes would provide excellent in vivo models for studies on human liver… Expand
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Highly Cited
1997
Highly Cited
1997
V(D)J recombination requires both lymphoid-specific and generally expressed enzymatic activities. All three known generally… Expand
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Highly Cited
1996
Highly Cited
1996
The proteins RAG-1 and RAG-2 are essential for initiation of V(D)J recombination. In dividing cells, RAG-2 accumulates during G1… Expand
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Highly Cited
1994
Highly Cited
1994
To study the role of B-cell antigen CD40 in immune responses, mouse embryonic stem (ES) cells in which both copies of the gene… Expand
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Highly Cited
1994
Highly Cited
1994
Detection of differentially regulated genes has been severely hampered by technical limitations. In an effort to overcome these… Expand
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Highly Cited
1994
Highly Cited
1994
The antigen receptors of B and T lymphocytes are encoded in multiple germ-line DNA segments that are joined during lymphocyte… Expand
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Highly Cited
1993
Highly Cited
1993
Antigen receptor genes are assembled by site-specific DNA rearrangement. The recombination activator genes RAG-1 and RAG-2 are… Expand
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Highly Cited
1992
Highly Cited
1992
We have generated mice that carry a germline mutation in which a large portion of the RAG-2 coding region is deleted. Homozygous… Expand
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Highly Cited
1990
Highly Cited
1990
The vast repertoire of immunoglobulins and T cell receptors is generated, in part, by V(D)J recombination, a series of genomic… Expand
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