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USP2 gene

Known as: UBIQUITIN-SPECIFIC PROTEASE, 41-KD, ubiquitin specific peptidase 2, UBP41 
 
National Institutes of Health

Papers overview

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2015
2015
USP2 promotes cell migration and invasion in triple negative breast cancer cell lines
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is often associated with a poor prognosis… Expand
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2012
2012
Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels.
BACKGROUND KCNQ1 (Kv7.1), together with its KCNE β subunits, plays a pivotal role both in the repolarization of cardiac tissue… Expand
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2012
2012
Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2
Endogenous 24-hour rhythms are generated by circadian clocks located in most tissues. The molecular clock mechanism is based on… Expand
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2011
2011
Mice Lacking the USP2 Deubiquitinating Enzyme Have Severe Male Subfertility Associated with Defects in Fertilization and Sperm Motility1
The ubiquitin-proteasome system plays an important role in spermatogenesis. However, the functions of deubiquitinating enzymes in… Expand
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2011
2011
The De-Ubiquitinylating Enzyme, USP2, Is Associated with the Circadian Clockwork and Regulates Its Sensitivity to Light
We have identified a novel component of the circadian clock that regulates its sensitivity to light at the evening light to dark… Expand
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2009
2009
Down-regulation of the de-ubiquitinating enzyme ubiquitin-specific protease 2 contributes to tumor necrosis factor-alpha-induced hepatocyte survival.
Tumor necrosis factor-alpha (TNFalpha) stimulation of hepatocytes induces either cell survival or apoptosis, which seems to be… Expand
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Highly Cited
2008
Highly Cited
2008
Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex.
Heterodimers of BMAL1 and CLOCK drive rhythmic expression of clock-controlled genes, thereby generating circadian physiology and… Expand
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Highly Cited
2006
Highly Cited
2006
Structural Basis of Ubiquitin Recognition by the Deubiquitinating Protease USP2
Summary Deubiquitinating proteases reverse protein ubiquitination and rescue their target proteins from destruction by the… Expand
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2003
2003
Gene structure, alternate splicing, tissue distribution, cellular localization, and developmental expression pattern of mouse deubiquitinating enzyme isoforms Usp2-45 and Usp2-69.
We have identified a novel mouse gene, Usp2, encoding two ubiquitin-specific proteases (USPs) due to alternate splicing of 5… Expand
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1998
1998
A novel family of ubiquitin-specific proteases in chick skeletal muscle with distinct N- and C-terminal extensions.
We have recently identified a cDNA for a ubiquitin-specific protease (UBP), UBP41, that encodes the smallest functional UBP… Expand
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