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UPF1 gene

Known as: UPF1, RNA helicase and ATPase, UPF1, UP Frameshift 1 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2.
Upf1 is a crucial factor in nonsense-mediated mRNA decay, the eukaryotic surveillance pathway that degrades mRNAs containing… Expand
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Highly Cited
2010
Highly Cited
2010
Upf1 ATPase-Dependent mRNP Disassembly Is Required for Completion of Nonsense- Mediated mRNA Decay
Cellular mRNAs exist in messenger ribonucleoprotein (mRNP) complexes, which undergo transitions during the lifetime of the mRNAs… Expand
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Highly Cited
2008
Highly Cited
2008
Inter‐kingdom conservation of mechanism of nonsense‐mediated mRNA decay
Nonsense‐mediated mRNA decay (NMD) is a quality control system that degrades mRNAs containing premature termination codons… Expand
Highly Cited
2006
Highly Cited
2006
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNA containing premature termination codons (PTCs… Expand
Highly Cited
2006
Highly Cited
2006
The Human RNA Surveillance Factor UPF1 Is Required for S Phase Progression and Genome Stability
The eukaryotic nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs carrying premature stop codons (PTC). In humans, NMD… Expand
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Highly Cited
2005
Highly Cited
2005
Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.
Decapping is a key step in mRNA turnover. However, the composition and regulation of the human decapping complex is poorly… Expand
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Highly Cited
2004
Highly Cited
2004
Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise
Premature termination codons induce rapid transcript degradation in eukaryotic cells through nonsense-mediated mRNA decay (NMD… Expand
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Highly Cited
2004
Highly Cited
2004
The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.
Members of the PI 3-kinase-related kinase (PIKK) family function in mitogenic and stress-induced signaling pathways in eukaryotic… Expand
Highly Cited
2001
Highly Cited
2001
SDE3 encodes an RNA helicase required for post‐transcriptional gene silencing in Arabidopsis
Post‐transcriptional gene silencing (PTGS) provides protection in plants against virus infection and can suppress expression of… Expand
Highly Cited
2000
Highly Cited
2000
Human Upf Proteins Target an mRNA for Nonsense-Mediated Decay When Bound Downstream of a Termination Codon
Nonsense-mediated decay (NMD) rids eukaryotic cells of aberrant mRNAs containing premature termination codons. These are… Expand
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