UPF1 gene

Known as: UPF1, RNA helicase and ATPase, UPF1, UP Frameshift 1 
 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that detects and degrades mRNAs containing premature termination… (More)
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Highly Cited
2011
Highly Cited
2011
Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2.
Upf1 is a crucial factor in nonsense-mediated mRNA decay, the eukaryotic surveillance pathway that degrades mRNAs containing… (More)
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Highly Cited
2010
Highly Cited
2010
Upf1 Senses 3′UTR Length to Potentiate mRNA Decay
The selective degradation of mRNAs by the nonsense-mediated decay pathway is a quality control process with important… (More)
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Highly Cited
2010
Highly Cited
2010
Upf1 ATPase-Dependent mRNP Disassembly Is Required for Completion of Nonsense- Mediated mRNA Decay
Cellular mRNAs exist in messenger ribonucleoprotein (mRNP) complexes, which undergo transitions during the lifetime of the mRNAs… (More)
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Highly Cited
2006
Highly Cited
2006
The Human RNA Surveillance Factor UPF1 Is Required for S Phase Progression and Genome Stability
The eukaryotic nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs carrying premature stop codons (PTC). In humans, NMD… (More)
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Highly Cited
2005
Highly Cited
2005
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
Eukaryotic cells coordinately regulate histone and DNA synthesis. In mammalian cells, most of the regulation of histone synthesis… (More)
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Highly Cited
2005
Highly Cited
2005
CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells
In mammalian cells, nonsense-mediated messenger RNA decay (NMD) targets newly synthesized nonsense-containing mRNA bound by the… (More)
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Highly Cited
2004
Highly Cited
2004
Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise
Premature termination codons induce rapid transcript degradation in eukaryotic cells through nonsense-mediated mRNA decay (NMD… (More)
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Highly Cited
2000
Highly Cited
2000
Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.
The Upf1 protein in yeast has been implicated in the modulation of efficient translation termination as well as in the… (More)
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Highly Cited
1998
Highly Cited
1998
A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells.
All eukaryotic cells analyzed have developed mechanisms to eliminate the production of mRNAs that prematurely terminate… (More)
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