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UNBS 1450

Known as: UNBS-1450, UNBS1450 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Cardenolides

Papers overview

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2016
2016
Cell type-dependent ROS and mitophagy response leads to apoptosis or necroptosis in neuroblastoma
A limiting factor in the therapeutic outcome of children with high-risk neuroblastoma is the intrinsic and acquired resistance to… Expand
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2015
2015
Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450
Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their… Expand
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2011
2011
UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells.
Cardiac steroids are used to treat various diseases including congestive heart failure and cancer. The aim of this study was to… Expand
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2009
2009
The sodium pump α1 sub-unit: a disease progression–related target for metastatic melanoma treatment
Melanomas remain associated with dismal prognosis because they are naturally resistant to apoptosis and they markedly metastasize… Expand
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Highly Cited
2008
Highly Cited
2008
Targeting the alpha 1 subunit of the sodium pump to combat glioblastoma cells.
OBJECTIVE Ion transporters play pivotal roles in cancer cell migration in general and in glioblastomas (GBMs) in particular… Expand
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2008
2008
Nucleolus and c-Myc: potential targets of cardenolide-mediated antitumor activity.
The use of cardenolides like ouabain, digitoxin, or oleandrin has been reported previously many times as a means of potentially… Expand
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Highly Cited
2007
Highly Cited
2007
The alpha1 subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers.
With an overall 5 year survival rate as low as 15% for non-small cell lung cancer (NSCLC), even with surgical intervention and… Expand
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Highly Cited
2006
Highly Cited
2006
Cardenolide-induced lysosomal membrane permeabilization demonstrates therapeutic benefits in experimental human non-small cell lung cancers.
Non-small cell lung cancers (NSCLCs) are the leading cause of cancer deaths in most developed countries. Targeting heat shock… Expand
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2006
2006
The cardenolide UNBS1450 is able to deactivate nuclear factor kappaB-mediated cytoprotective effects in human non-small cell lung cancer cells.
Non-small cell lung cancers (NSCLC) are associated with very dismal prognoses, and adjuvant chemotherapy, including irinotecan… Expand
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2006
2006
The cardenolide UNBS 1450 is able to deactivate nuclear factor K B – mediated cytoprotective effects in human non – small cell lung cancer cells
Non–small cell lung cancers (NSCLC) are associated with very dismal prognoses, and adjuvant chemotherapy, including irinotecan… Expand
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