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The objectives of this study were to assess the role of mitochondrial pyruvate carriers (MPCs) in adipocyte development in vitro… Expand Target engagement assays are crucial for establishing the mechanism-of-action of small molecules in living systems. Integral… Expand The nature and existence of mitochondrial lactate oxidation is debated in the literature. Obscuring the issue are disparate… Expand IntroductionWe hypothesize that the combination of transarterial embolization (TAE) plus inhibition of lactate export will limit… Expand The properties of the conductive Cl- transport pathway underlying regulatory volume decrease (RVD) in human neutrophils were… Expand When subjected to hypotonic stress, human peripheral neutrophils initially swell due to rapid water entry and thereafter recover… Expand The pathway by which L-lactate (Lac) crosses the plasma membrane of isolated human neutrophils was investigated. The influx of… Expand The nature of the intracellular pH-regulatory mechanism after imposition of an alkaline load was investigated in isolated human… Expand As part of our ongoing studies aimed at understanding the physiology of human neutrophil function, we have been investigating the… Expand Some of the known inhibitors of pyruvate transport inhibited the activity of carnitine-acylcarnitine translocase. Their order of… Expand