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UK 101

Known as: UK-101, UK101 cpd 
National Institutes of Health

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2 relations

Broader (2)

DipeptidesOrganosilicon Compounds

Papers overview

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2016
2016
Abstract 3071: Proteasome subunit composition contributes to unusually poor sensitivity of H727 cells to carfilzomib
Background: While proteasome inhibitors (PIs) have significantly improved the survival of multiple myeloma (MM) patients… 
2012
2012
Nitric oxide-dependent CYP2B degradation is potentiated by a cytokine-regulated pathway and utilizes the immunoproteasome subunit LMP2
CYP2B proteins in rat hepatocytes undergo NO-dependent proteolytic degradation, but the mechanisms and the reasons for the… 
2011
2011
Target validation of UK-101 and functional studies of beta1i
OF DISSERTATION TARGET VALIDATION OF UK-101 AND FUNCTIONAL STUDIES OF β1i β1i is a major catalytic subunit of the… 
2011
2011
Abstract 2621: Development of Fluoro-UK-101, an immunoproteasome-targeting activity-based fluorescent probe
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Introduction: This study was conducted to develop the… 
2011
2011
Abstract 2611: Inhibition of the immunoproteasome subunit LMP2 by UK-101 leads to apoptosis and cell cycle arrest in pancreatic cancer
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Background: The immunoproteasome is an alternative form… 
2011
2011
Abstract 2616: The immunoproteasome subunit LMP2 as a novel therapeutic target for non-small cell lung cancer
Introduction: Lung cancer, although not the most commonly diagnosed form of cancer, is the leading cause of cancer deaths in the… 
2010
2010
Abstract 2624: Targeted inhibition of the immunoproteasome subunit LMP2 using UK-101 induces apoptotic cell death in colorectal cancer
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC Background: The immunoproteasome is an alternative… 
2010
2010
Abstract 2631: Target validation of the LMP2 inhibitor, UK-101
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