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UGT1A9 protein, human

Known as: lugP4, UDP-Glucuronosyltransferase 1-I, UGT-1I 
UDP-glucuronosyltransferase 1-9 (530 aa, ~60 kDa) is encoded by the human UGT1A9 gene. This protein is involved in the metabolism of phenolic… 
National Institutes of Health

Related topics

Related topics

13 relations
Carbohydrate MetabolismEnzyme GeneGlycosyltransferase GeneLiver parenchyma

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Determination of propofol UDP-glucuronosyltransferase (UGT) activities in hepatic microsomes from different species by UFLC-ESI-MS.
Highly Cited
2011
Highly Cited
2011
Conjugation of Synthetic Cannabinoids JWH-018 and JWH-073, Metabolites by Human UDP-Glucuronosyltransferases
K2, a synthetic cannabinoid (SC), is an emerging drug of abuse touted as “legal marijuana” and marketed to young teens and first… 
Highly Cited
2010
Highly Cited
2010
Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes.
Glucuronidation catalyzed by UDP-glucuronosyltransferase (UGT) enzymes is an important pathway in the metabolism of drugs as well… 
2008
2008
Hepatocyte nuclear factor-1 alpha is associated with UGT1A1, UGT1A9 and UGT2B7 mRNA expression in human liver
Experimental evidence suggests HNF1α regulates UGT expression. This study investigates (1) whether the variability in HNF1… 
2007
2007
Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3 and UGT1A4 mRNA in human livers.
UDP-glucuronosyltransferases (UGTs) catalyze phase-II biotransformation reaction of a variety of substances. Among the UGT1A… 
2007
2007
Influence of UGT1A7 and UGT1A9 Intronic I399 Genetic Polymorphisms on Mycophenolic Acid Pharmacokinetics in Japanese Renal Transplant Recipients
Abstract: UGT1A7 and UGT1A9 are uridine diphosphate-glucuronosyltransferase isoforms involved in the glucuronidation of… 
Highly Cited
2006
Highly Cited
2006
N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler…
Highly Cited
2005
Highly Cited
2005
Effects of Ketoconazole on Glucuronidation by UDP-Glucuronosyltransferase Enzymes
Purpose: Ketoconazole has been shown to inhibit the glucuronidation of the UGT2B7 substrates zidovudine and lorazepam. Its effect… 
Highly Cited
2003
Highly Cited
2003
Effects of dimethyl sulfoxide on the gene induction of cytochrome P450 isoforms, UGT-dependent glucuronosyl transferase isoforms, and ABCB1 in primary culture of human hepatocytes.
We investigated the gene expression of GAPDH, cytochrome P450 isoforms (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2E1, CYP3A4, CYP3A5… 
2001
2001
Glucuronidation of 1-hydroxypyrene by human liver microsomes and human UDP-glucuronosyltransferases UGT1A6, UGT1A7, and UGT1A9: development of a high-sensitivity glucuronidation assay for human…
Human UDP-glucuronosyltransferases (UGT, EC 2.4.1.17) involved in the biotransformation of pyrene were investigated by a… 
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