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UGT1A9 gene

Known as: UGT1A9, LUGP4, HLUGP4 
This gene is involved in phenol detoxification.
National Institutes of Health

Related topics

Related topics

3 relations
Metabolic Detoxication, DrugUGT1A9 protein, humanglycosylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes.
Glucuronidation catalyzed by UDP-glucuronosyltransferase (UGT) enzymes is an important pathway in the metabolism of drugs as well… 
Highly Cited
2008
Highly Cited
2008
Glucuronidation of flavonoids by recombinant UGT1A3 and UGT1A9.
Highly Cited
2007
Highly Cited
2007
Effects of Coexpression of UGT1A9 on Enzymatic Activities of Human UGT1A Isoforms
We established stable HEK293 cell lines expressing double isoforms, UGT1A1 and UGT1A9, UGT1A4 and UGT1A9, or UGT1A6 and UGT1A9… 
2007
2007
Influence of UGT1A7 and UGT1A9 Intronic I399 Genetic Polymorphisms on Mycophenolic Acid Pharmacokinetics in Japanese Renal Transplant Recipients
Abstract: UGT1A7 and UGT1A9 are uridine diphosphate-glucuronosyltransferase isoforms involved in the glucuronidation of… 
2007
2007
Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3 and UGT1A4 mRNA in human livers.
UDP-glucuronosyltransferases (UGTs) catalyze phase-II biotransformation reaction of a variety of substances. Among the UGT1A… 
Highly Cited
2006
Highly Cited
2006
THE NOVEL UGT1A9 INTRONIC I399 POLYMORPHISM APPEARS AS A PREDICTOR OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN GLUCURONIDATION LEVELS IN THE LIVER
Polymorphisms in UGT1A9 were associated with reduced toxicity and increased response to irinotecan in cancer patients. UDP… 
Highly Cited
2005
Highly Cited
2005
Hepatic Expression of the UGT1A9 Gene Is Governed by Hepatocyte Nuclear Factor 4α
UDP-glucuronosyltransferase (UGT) enzymes catalyze the glucuronidation reaction, which is a major pathway in the catabolism and… 
Highly Cited
2003
Highly Cited
2003
Functional Characterization of Human UDP-Glucuronosyltransferase 1A9 Variant, D256N, Found in Japanese Cancer Patients
SN-38 (7-ethyl-10-hydroxycamptothecin), an active metabolite of the antitumor prodrug irinotecan, is conjugated and detoxified to… 
Highly Cited
2002
Highly Cited
2002
Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes.
UDP-glucuronosyltransferase (UGT)-mediated glucuronidation of benzo(a)pyrene-trans-7,8-dihydrodiol (BPD), precursor to the potent… 
Highly Cited
1993
Highly Cited
1993
Paracetamol glucuronidation by recombinant rat and human phenol UDP-glucuronosyltransferases.
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