UGT1A1 protein, human

Known as: UDPGT 1-1, UDP glycosyltransferase 1 family, polypeptide A1, human, UDP-Glucuronosyltransferase 1-1 
UDP-glucuronosyltransferase 1-1 (533 aa, ~60 kDa) is encoded by the human UGT1A1 gene. This protein is involved in the glucuronidation of bilirubin… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2018
05010019922018

Papers overview

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Highly Cited
2007
Highly Cited
2007
OBJECTIVES SN-38, an active metabolite of irinotecan, is detoxified by glucuronidation with UGT1A isoforms, 1A1, 1A7, 1A9, and… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Bilirubin is an antioxidant that suppresses lipid oxidation and retards atherosclerosis formation. An inverse… (More)
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Highly Cited
2002
Highly Cited
2002
The metabolism of irinotecan (CPT-11) involves sequential activation to SN-38 and detoxification to the pharmacologically… (More)
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Highly Cited
2001
Highly Cited
2001
The UDP-glucuronosyltransferase, UGT1A1, is the critical enzyme responsible for detoxification of the potentially neurotoxic… (More)
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Highly Cited
2001
Highly Cited
2001
We used expression microarrays to test the effects of rifampin on the overall pattern of mRNA expression of multiple metabolic… (More)
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Highly Cited
2000
Highly Cited
2000
We examined the role of constitutional genetic variation at the UDP-glucuronosyltransferase (UGT) 1A1 locus in breast cancer… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Hepatic uridine diphosphate glucuronosyltransferase (UGT) isoform 1A1 (UGT1A1) is primarily responsible for the… (More)
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Highly Cited
1999
Highly Cited
1999
Polymorphisms that alter UDP-glucuronosyltransferase (UGT) activities have been identified. Mutations in the promoter of the… (More)
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Highly Cited
1998
Highly Cited
1998
Irinotecan (CPT-11) is a promising antitumor agent, recently approved for use in patients with metastatic colorectal cancer. Its… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND The genetic basis of Gilbert's syndrome is ill-defined. This common mild hyperbilirubinaemia sometimes presents as an… (More)
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