FAQ

UDP-N-acetylmuramate-L-alanine ligase activity

Known as: UDP-N-acetylmuramate:L-alanine ligase (ADP-forming), UDP-MurNAc:L-alanine ligase activity, UDPMurNAc-L-alanine synthetase activity 
Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanine. [EC:6.3.2.8, RHEA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1973-2016
01219732016

Papers overview

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2011
2011
Inducible L-alanine exporter encoded by the novel gene ygaW (alaE) in Escherichia coli.
We previously isolated a mutant hypersensitive to L-alanyl-L-alanine from a non-L-alanine-metabolizing Escherichia coli strain… (More)
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2006
2006
Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5.
UDPMurNAc-L-Ala-gamma-D-Glu-X-D-Ala-DAla (X = L-Lys or m-DAP) is the cytoplasmic precursor for the lipid-linked cycle of… (More)
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2005
2005
Uptake and Metabolism of L-alanine by Freshly Isolated Trout (salmo Trutta) Hepatocytes: the Effect of Fasting
Uptake and metabolism of L-alanine by freshly isolated trout hepatocytes has been analyzed. This amino acid is incorporated… (More)
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2004
2004
Antioxidant action of L-alanine: heme oxygenase-1 and ferritin as possible mediators.
The amino acid L-alanine has been shown to exert long-term cytoprotection by as yet unidentified molecular mechanisms. Using… (More)
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2002
2002
Benzylidene rhodanines as novel inhibitors of UDP-N-acetylmuramate/L-alanine ligase.
Benzylidene rhodanines are novel inhibitors of UDP N-acetylmuramate/L-alanine ligase. They showed selective whole-cell activity… (More)
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2002
2002
A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine…
Early experiments indicated that islet beta-cells substantially metabolized L-alanine but that insulin secretion was largely… (More)
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2002
2002
A Nuclear Magnetic Resonance–Based Demonstration of Substantial Oxidative L-Alanine Metabolism and L-Alanine–Enhanced Glucose Metabolism in a Clonal Pancreatic -Cell Line Metabolism of L-Alanine Is…
Early experiments indicated that islet -cells substantially metabolized L-alanine but that insulin secretion was largely… (More)
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1997
1997
Evaluation of the kinetic mechanism of Escherichia coli uridine diphosphate-N-acetylmuramate:L-alanine ligase.
Initial velocity methods were used to probe the kinetic mechanism of Escherichia coli uridine diphosphate-N-acetylmuramate:L… (More)
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1996
1996
Biochemical evidence for the formation of a covalent acyl-phosphate linkage between UDP-N-acetylmuramate and ATP in the Escherichia coli UDP-N-acetylmuramate:L-alanine ligase-catalyzed reaction.
In the peptidoglycan biosynthesis pathway in Escherichia coli, UDP-N-acetylmuramate:L-alanine ligase (MurC) catalyzes the… (More)
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1996
1996
The clp (CS31A) operon is negatively controlled by Lrp, ClpB, and L-alanine at the transcriptional level.
Biosynthesis of the Escherichia coli CS31A surface antigen was subject to phase-variation control and repressed by L-alanine… (More)
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