UDP-Glucuronosyltransferase 2B15

Known as: UDPGTh-3, UDP Glycosyltransferase 2 Family, Member B15, UDPGT 2B15 
UDP-glucuronosyltransferase 2B15 (530 aa, ~61 kDa) is encoded by the human UGT2B15 gene. This protein is involved in the catabolism of xenobiotics… (More)
National Institutes of Health

Related topics

Related topics

11 relations
Carbohydrate MetabolismEnzyme GeneGlycosyltransferase GenePentose and Glucuronate Interconversions Pathway
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Effect of UDP-glucuronosyltransferase 2B15 polymorphism on bisphenol A glucuronidation
Bisphenol A (BPA) is one of a number of potential endocrine-disrupting chemicals, which are metabolized mainly by UDP… (More)
  • table 1
  • table 2
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
2011
2011
Characterization of niflumic acid as a selective inhibitor of human liver microsomal UDP-glucuronosyltransferase 1A9: application to the reaction phenotyping of acetaminophen glucuronidation.
Enzyme selective inhibitors represent the most valuable experimental tool for reaction phenotyping. However, only a limited… (More)
  • table 2
  • table 3
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Human UDP-glucuronosyltransferase isoforms involved in bisphenol A glucuronidation.
Bisphenol A (BPA) is one of a number of potential endocrine disruptors which may affect normal hormonal function. In this study… (More)
Is this relevant?
2008
2008
Inactivation by UDP-glucuronosyltransferase enzymes: The end of androgen signaling
Conjugation by UDP-Glucuronosyltransferase (UGT) is the major pathway of androgen metabolism and elimination in the human. High… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer
Tamoxifen therapy reduces the risk of recurrence and prolongs the survival of oestrogen-receptor-positive patients with breast… (More)
  • table 1
  • figure 1
  • table 2
  • figure 3
  • figure 2
Is this relevant?
2005
2005
Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers.
OBJECTIVE Our objective was to investigate the effect of the uridine 5'-diphosphate-glucuronosyltransferase (UGT) 2B15 genetic… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9.
(R,S)-Oxazepam is a 1,4-benzodiazepine anxiolytic drug that is metabolized primarily by hepatic glucuronidation. In previous… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members.
Androgens and estrogens play major roles in cell differentiation, cell growth, and peptide secretion in steroid target tissues… (More)
Is this relevant?
Review
1998
Review
1998
Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues
Conjugation of compounds by glucuronidation is a pathway found in all vertebrates studied to date. Although, it is widely… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates.
A full-length cDNA clone (HE8a) for a human hepatic UDP-glucuronosyltransferase was isolated from a human liver cDNA library and… (More)
Is this relevant?