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UCP1 wt Allele

Known as: SLC25A7, UCP, Uncoupling Protein 1 (Mitochondrial, Proton Carrier) wt Allele 
Human UCP1 wild-type allele is located within 4q28-q31 and is approximately 9 kb in length. This allele, which encodes mitochondrial brown fat… 
National Institutes of Health

Related topics

Related topics

7 relations
4q28-q31Cell RespirationHomo sapiensIonophore activity

Papers overview

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Review
2010
Review
2010
Mitochondrial uncoupling proteins in unicellular eukaryotes.
Review
2001
Review
2001
Genetic and physiological analysis of the role of uncoupling proteins in human energy homeostasis
Abstract. The metabolic utilization of substrates results in ATP synthesis and energy loss as heat. In tissues and cells the… 
Highly Cited
2001
Highly Cited
2001
Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARα-mediated pathway
The discovery of homologs of the brown fat uncoupling protein(s) (UCP) UCP-2 and UCP-3 revived the hypothesis of uncoupling… 
Highly Cited
2001
Highly Cited
2001
Insulin and contraction directly stimulate UCP2 and UCP3 mRNA expression in rat skeletal muscle in vitro.
To study the regulation of the mitochondrial uncoupling protein 2 and 3 (UCP2 and UCP3), we studied the effect of insulin and… 
Highly Cited
1996
Highly Cited
1996
Activation of the uncoupling protein by fatty acids is modulated by mutations in the C-terminal region of the protein.
The transport properties of the uncoupling protein (UCP) from brown adipose tissue have been studied in mutants where Cys304 has… 
Highly Cited
1995
Highly Cited
1995
Functional assessment of white and brown adipocyte development and energy metabolism in cell culture. Dissociation of terminal differentiation and thermogenesis in brown adipocytes.
We investigated the effect of insulin, triiodothyronine (T3) and dexamethasone (a synthetic glucocorticoid) on differentiation… 
Highly Cited
1992
Highly Cited
1992
Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene.
Transgenic mice were produced containing the adipocyte-specific regulatory region from the adipocyte P2 (aP2) gene linked to the… 
Highly Cited
1991
Highly Cited
1991
Development of Phodopus sungorus brown preadipocytes in primary cell culture: effect of an atypical beta-adrenergic agonist, insulin, and triiodothyronine on differentiation, mitochondrial…
A new cellular model for the study of brown adipocyte development and differentiation in vitro is presented. Preadipocytes… 
Highly Cited
1990
Highly Cited
1990
Synthesis of mitochondrial uncoupling protein in brown adipocytes differentiated in cell culture.
Highly Cited
1988
Highly Cited
1988
Full expression of uncoupling protein gene requires the concurrence of norepinephrine and triiodothyronine.
We have examined the uncoupling (UCP) protein gene expression in euthyroid and hypothyroid rats. UCP mRNA levels were estimated… 
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