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U-78779

National Institutes of Health

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bizelesin

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2002
2002
The genome factor in region-specific DNA damage: the DNA-reactive drug U-78779 prefers mixed A/T-G/C sequences at the nucleotide level but is region-specific for long pure AT islands at the genomic…
Bizelesin is the first anticancer drug capable of damaging specific regions of the genome with clusters of its binding sites T(A… 
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