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U 76073

Known as: U-76,073, U-76073 
 
National Institutes of Health

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2 relations

Broader (2)

BenzofuransIndoles

Papers overview

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1999
1999
Phase I study of Carzelesin (U-80,244) given (4-weekly) by intravenous bolus schedule
SummaryCarzelesin is a cyclopropylpyrroloindole analogue which acts as a DNA-sequence-specific alkylating agent. In this phase I… Expand
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1998
1998
A clinical pharmacokinetics study of carzelesin given by short-term intravenous infusion in a phase I study
Abstract We investigated the pharmacokinetic behavior of carzelesin in 31 patients receiving this drug by 10-min intravenous… Expand
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1996
1996
Phase I clinical and pharmacokinetic study of carzelesin (U-80244) given daily for five consecutive days.
Carzelesin (U-80244), one of the synthetic DNA minor groove binding cyclopropylpyrroloindole analogues, was selected for clinical… Expand
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1996
1996
Systematic study on the chemical stability of the prodrug antitumor agent carzelesin (U-80,244)
The chemical stability of the novel anticancer agent carzelesin in aqueous buffer/acetonitrile (1:1, v/v) mixtures has been… Expand
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1994
1994
Fully automated high-performance liquid chromatographic method for the determination of carzelesin (U-80,244) and metabolites (U-76,073 and U-76,074) in human plasma.
Carzelesin (U80,244, I) is a cyclopropylpyrroloindole prodrug analog. The compound exerts its cytotoxic activity after conversion… Expand
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Highly Cited
1992
Highly Cited
1992
Cytotoxicity and antitumor activity of carzelesin, a prodrug cyclopropylpyrroloindole analogue.
The cyclopropylpyrroloindole analogues are DNA minor-groove binders containing a cyclopropyl group, which mediates N3-adenine… Expand
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