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Tyrosyl-DNA Phosphodiesterase 1

Known as: EC 3.1.4.-, TDP1, Tyr-DNA Phosphodiesterase 1 
Tyrosyl-DNA phosphodiesterase 1 (608 aa, ~68 kDa) is encoded by the human TDP1 gene. This protein plays a role in single and double strand break… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Background: Tdp1 is a DNA repair enzyme conserved across eukaryotes. Results: Tdp1 repairs not only 3′-tyrosyl-DNA bonds and 3… Expand
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Highly Cited
2009
Highly Cited
2009
Topoisomerases regulate DNA topology and are fundamental to many aspects of chromosome metabolism. Their activity involves the… Expand
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Highly Cited
2006
Highly Cited
2006
Agents targeting topoisomerases are active against a wide range of human tumors. Stabilization of covalent complexes, converting… Expand
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Highly Cited
2005
Highly Cited
2005
Spinocerebellar ataxia with axonal neuropathy-1 (SCAN1) is a neurodegenerative disease that results from mutation of tyrosyl… Expand
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Highly Cited
2005
Highly Cited
2005
Tyrosyl‐DNA phosphodiesterase (Tdp1) catalyzes the hydrolysis of the tyrosyl‐3′ phosphate linkage found in topoisomerase I–DNA… Expand
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Review
2003
Review
2003
DNA single-strand break repair (SSBR) is critical for the survival and genetic stability of mammalian cells. Three papers have… Expand
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Highly Cited
2002
Highly Cited
2002
Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs covalently bound topoisomerase I–DNA complexes and is essential for preventing the… Expand
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Highly Cited
2002
Highly Cited
2002
Tyrosyl-DNA phosphodiesterase-1 (Tdp1) is the only known enzyme to remove tyrosine from complexes in which the amino acid is… Expand
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Highly Cited
2002
Highly Cited
2002
Accidental or drug-induced interruption of the breakage and reunion cycle of eukaryotic topoisomerase I (Top1) yields complexes… Expand
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Highly Cited
2001
Highly Cited
2001
The phospholipase D (PLD) superfamily is a diverse group of proteins that includes enzymes involved in phospholipid metabolism, a… Expand
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