Tyrosyl-DNA Phosphodiesterase 1

Known as: EC 3.1.4.-, TDP1, Tyr-DNA Phosphodiesterase 1 
Tyrosyl-DNA phosphodiesterase 1 (608 aa, ~68 kDa) is encoded by the human TDP1 gene. This protein plays a role in single and double strand break… (More)
National Institutes of Health

Papers overview

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2016
2016
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a repair enzyme for stalled DNA-topoisomerase 1 (Top1) cleavage complexes and other 3… (More)
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Review
2014
Review
2014
TDP1 and TDP2 were discovered and named based on the fact they process 3'- and 5'-DNA ends by excising irreversible protein… (More)
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Highly Cited
2012
Highly Cited
2012
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) repairs topoisomerase I cleavage complexes (Top1cc) by hydrolyzing their 3'-phosphotyrosyl… (More)
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2012
2012
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) catalyzes the hydrolysis of the phosphodiester linkage between the DNA 3' phosphate and a… (More)
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2011
2011
TDP (tyrosyl-DNA phosphodiesterase) 1 catalyses the hydrolysis of phosphodiester linkages between a DNA 3' phosphate and a… (More)
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Highly Cited
2009
Highly Cited
2009
Topoisomerases regulate DNA topology and are fundamental to many aspects of chromosome metabolism. Their activity involves the… (More)
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Highly Cited
2005
Highly Cited
2005
Spinocerebellar ataxia with axonal neuropathy-1 (SCAN1) is a neurodegenerative disease that results from mutation of tyrosyl… (More)
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2002
2002
Tyrosyl-DNA phosphodiesterase (Tdp1) catalyzes the hydrolysis of a phosphodiester bond between a tyrosine residue and a DNA 3… (More)
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Highly Cited
2002
Highly Cited
2002
Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs covalently bound topoisomerase I–DNA complexes and is essential for preventing the… (More)
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Highly Cited
2001
Highly Cited
2001
The phospholipase D (PLD) superfamily is a diverse group of proteins that includes enzymes involved in phospholipid metabolism, a… (More)
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