Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Tyrosine-Protein Kinase Lck, Human

Known as: Leukocyte C-Terminal Src Kinase, EC 2.7.1.112, LSK 
Tyrosine-protein kinase Lck (509 aa, ~58 kDa) is encoded by the human LCK gene. This protein is involved in tyrosine phosphorylation, T-cell… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Phosphorylation of the T cell antigen receptor (TCR) by the tyrosine kinase Lck is an essential step in the activation of T cells… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2008
Highly Cited
2008
The pathways by which oncogenes, such as MLL-AF9, initiate transformation and leukemia in humans and mice are incompletely… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Although glucocorticoid (GC)-induced nongenomic effects have been reported, the underlying mechanisms remain unexplained. We… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Review
2004
Review
2004
The function of the Src-family kinases (SFKs) Lck and Fyn in T cells has been intensively studied over the past 15 years. Animal… Expand
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
2004
Highly Cited
2004
In T lymphocytes, the Src family kinase Lck associates lipid rafts and accumulates at the immunological synapse (IS) during T… Expand
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Lipid rafts are specialized plasma membrane microdomains, in which glycosphingolipids and cholesterol are major structural… Expand
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Although dispensable, costimulation through CD28 facilitates activation of naïve T lymphocytes. CD28 engagement led to the… Expand
Is this relevant?
Highly Cited
1999
Highly Cited
1999
The role of lipid rafts in T cell antigen receptor (TCR) signaling was investigated using fluorescence microscopy. Lipid rafts… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1997
Highly Cited
1997
LCK is a non-receptor protein tyrosine kinase required for signal transduction via the T-cell antigen receptor (TCR). LCK N… Expand
  • table I
  • figure 1
  • figure 3
  • figure 2
  • figure 4
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Lck, a Src family tyrosine kinase, transduces signals important for the development of alphabeta and gammadelta T cells. However… Expand
Is this relevant?