Tyrosine-Protein Kinase Lck, Human

Known as: Leukocyte C-Terminal Src Kinase, EC 2.7.1.112, LSK 
Tyrosine-protein kinase Lck (509 aa, ~58 kDa) is encoded by the human LCK gene. This protein is involved in tyrosine phosphorylation, T-cell… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2018
0102019862018

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Highly Cited
2006
Highly Cited
2006
Although glucocorticoid (GC)-induced nongenomic effects have been reported, the underlying mechanisms remain unexplained. We… (More)
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Highly Cited
2004
Highly Cited
2004
Systemic lupus erythematosus (SLE) is characterized by abnormalities in T lymphocyte receptor-mediated signal transduction… (More)
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Highly Cited
2000
Highly Cited
2000
The T lymphocyte-specific protein tyrosine kinase p56lck (Lck) is an essential component of the TCR-mediated signal transduction… (More)
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Highly Cited
1998
Highly Cited
1998
Mitogen stimulation of cytoskeletal changes and c-jun amino-terminal kinases is mediated by Rac small guanine nucleotide-binding… (More)
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1998
1998
HLA-specific killer cell inhibitory receptors (KIR) are thought to impede natural killer (NK) and T cell activation programs… (More)
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Highly Cited
1997
Highly Cited
1997
LCK is a non-receptor protein tyrosine kinase required for signal transduction via the T-cell antigen receptor (TCR). LCK N… (More)
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Highly Cited
1996
Highly Cited
1996
The Src-family and Syk/ZAP-70 family of protein tyrosine kinases (PTK) are required for T cell receptor (TCR) functions. We… (More)
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Highly Cited
1996
Highly Cited
1996
Lck, a Src family tyrosine kinase, transduces signals important for the development of alphabeta and gammadelta T cells. However… (More)
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Highly Cited
1993
Highly Cited
1993
Signals transduced through the T cell antigen receptor (TCR) are modulated by the src family tyrosine kinase p56lck (lck), which… (More)
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Highly Cited
1992
Highly Cited
1992
Signaling through the T cell antigen receptor (TCR) results both in rapid increases in tyrosine phosphorylation on a number of… (More)
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