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Tyrosine-Protein Kinase ABL1, human

Known as: c-ABL Protein, ABL1, Proto-Oncogene c-Abl 
Tyrosine-protein kinase ABL1 (1130 aa, ~123 kDa) is encoded by the human ABL1 gene. This protein is involved in tyrosine phosphorylation, signal… 
National Institutes of Health

Related topics

Related topics

28 relations
ABL1 geneATM Signaling PathwayApoptosisAxon Guidance

Broader (1)

Proto-Oncogene Proteins c-abl

Papers overview

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Highly Cited
2018
Highly Cited
2018
Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.
Chronic myelogenous leukemia (CML) arises from the constitutive activity of the BCR-ABL1 oncoprotein. Tyrosine kinase inhibitors… 
Highly Cited
2014
Highly Cited
2014
RESCUE OF HIPPO CO-ACTIVATOR YAP1 TRIGGERS DNA DAMAGE-INDUCED APOPTOSIS IN HEMATOLOGICAL CANCERS
Oncogene-induced DNA damage elicits genomic instability in epithelial cancer cells, but apoptosis is blocked through inactivation… 
Highly Cited
2008
Highly Cited
2008
BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
The Philadelphia chromosome, a chromosomal abnormality that encodes BCR–ABL1, is the defining lesion of chronic myelogenous… 
Highly Cited
2004
Highly Cited
2004
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia
In T-cell acute lymphoblastic leukemia (T-ALL), transcription factors are known to be deregulated by chromosomal translocations… 
Highly Cited
2000
Highly Cited
2000
Reversibility of acute B-cell leukaemia induced by BCR–ABL1
Cancer is thought to arise from multiple genetic events that establish irreversible malignancy. A different mechanism might be… 
Highly Cited
1998
Highly Cited
1998
An intramolecular SH3-domain interaction regulates c-Abl activity
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase (c-Abl) that has been implicated in processes… 
Highly Cited
1997
Highly Cited
1997
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
Huntington's disease (HD) is an inherited neurodegenerative disease caused by expansion of a polyglutamine repeat in the HD… 
Highly Cited
1997
Highly Cited
1997
Characterization of p150, an Adaptor Protein for the Human Phosphatidylinositol (PtdIns) 3-Kinase
Genetic and biochemical studies have shown that the phosphatidylinositol (PtdIns) 3-kinase encoded by the yeast VPS34 gene is… 
Highly Cited
1992
Highly Cited
1992
Cell Cycle—Regulated Binding of c-Abl Tyrosine Kinase to DNA
The proto-oncogene c-abl encodes a protein tyrosine kinase that is localized in the cytoplasm and the nucleus. The large carboxyl… 
Highly Cited
1990
Highly Cited
1990
Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.
Oncogenic activation of the proto-oncogene c-abl in human leukemias occurs as a result of the addition of exons from the gene bcr… 
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