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In the 30 years since its discovery, tyrosine phosphorylation has emerged as a fundamentally important mechanism of signal… Expand Tyrosine kinases play a prominent role in human cancer, yet the oncogenic signaling pathways driving cell proliferation and… Expand Receptor desensitization is accomplished by accelerated endocytosis and degradation of ligand-receptor complexes. An in vitro… Expand The large extracellular matrix protein Reelin is produced by Cajal-Retzius neurons in specific regions of the developing brain… Expand The linker molecule LAT is a critical substrate of the tyrosine kinases activated upon TCR engagement. Phosphorylated LAT binds… Expand Recent studies have indicated that serine phosphorylation regulates the activities of STAT1 and STAT3. However, the kinase(s… Expand The molecular basis of mammalian sperm capacitation, defined functionally as those processes that confer on the sperm the… Expand In the accompanying report (Visconti, P.E., Bailey, J.L., Moore, G.D., Pan, D., Olds-Clarke, P. and Kopf, G.S. (1995) Development… Expand NERVE growth factor (NGF) is a neurotrophic factor responsible for the differentiation and survival of sympathetic and sensory… Expand The cdc2+ protein kinase (pp34) is found to be phosphorylated on tyrosine as well as serine and threonine residues in… Expand