Tyrosine Kinase Inhibitors [MoA]

Known as: Tyrosine Kinase Inhibitors 
 
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-ABL1 in a hemopoietic stem cell… (More)
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Highly Cited
2012
Highly Cited
2012
Most anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancers (NSCLCs) are highly responsive to treatment with ALK… (More)
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Highly Cited
2010
Highly Cited
2010
Ten percent of North American patients with non-small-cell lung cancer have tumors with somatic mutations in the gene for the… (More)
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Highly Cited
2010
Highly Cited
2010
The standard of care for managing patients with gastrointestinal stromal tumors (GISTs) rapidly changed after the introduction of… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE The EML4-ALK fusion oncogene represents a novel molecular target in a small subset of non-small-cell lung cancers (NSCLC… (More)
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Highly Cited
2008
Highly Cited
2008
Lung cancers caused by activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to small… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Somatic mutations in the epidermal growth factor receptor (EGFR) correlate with increased response in patients with non… (More)
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Highly Cited
2007
Highly Cited
2007
Oncogenic tyrosine kinases have proved to be promising targets for the development of highly effective anticancer drugs. However… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE In patients whose lung adenocarcinomas harbor epidermal growth factor receptor (EGFR) tyrosine kinase domain mutations… (More)
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Review
2005
Review
2005
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB receptor family that is abnormally… (More)
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