Tumor Suppressor Gene Inactivation Process

Known as: Tumor Suppressor Gene Inactivation 
Any DNA sequence alteration process occurring in a tumor suppressor gene, resulting in loss of function of the gene product, and predisposing the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2017
024619912017

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2010
2010
Late relapse of breast cancer can occur more than 25 years after primary diagnosis. During the intervening years between initial… (More)
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Highly Cited
2010
Highly Cited
2010
Pheochromocytomas, which are catecholamine-secreting tumors of neural crest origin, are frequently hereditary. However, the… (More)
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2008
2008
Lung cancer is the leading cause of cancer death in men and women in the United States and Western Europe. Over 160,000 Americans… (More)
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2006
2006
BACKGROUND & AIMS Multiple studies have shown that promoter methylation of tumor suppressor genes underlies esophageal… (More)
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2006
2006
Epigenetic alterations and loss of heterozygosity are mechanisms of tumor suppressor gene inactivation. A new carcinogenic… (More)
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Highly Cited
2005
Highly Cited
2005
Prostate cancer is a leading and increasingly prevalent cause of cancer death in men. Whereas family history of disease is one of… (More)
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Highly Cited
2001
Highly Cited
2001
Loss of heterozygosity and mutations in the PTEN (MMAC1) tumor suppressor gene are frequent in endometrial carcinoma. Promoter… (More)
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2001
2001
DNA hypermethylation of CpG-rich promoter sequences is associated with tumor suppressor gene inactivation in many human cancers… (More)
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Highly Cited
1999
Highly Cited
1999
CpG island methylation has been linked to tumor suppressor gene inactivation in neoplasia and may serve as a useful marker to… (More)
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1994
1994
Reactive oxygen species produced by normal cellular metabolism have been considered to play a causative role in spontaneously… (More)
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