Tubulin Binding Agent

Known as: Tubulin Binding Agents, antimicrotubule agent 
A type of drug that blocks cell growth by stopping mitosis (cell division). Antimicrotubule agents interfere with microtubules (cellular structures… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2016
051019912016

Papers overview

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2014
2014
PM060184 belongs to a new family of tubulin-binding agents originally isolated from the marine sponge Lithoplocamia lithistoides… (More)
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2014
2014
BACKGROUND In a murine anthracycline-related cardiotoxicity model, increases in cardiovascular magnetic resonance myocardial… (More)
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2013
2013
BACKGROUND Antimitotic agents are essential components for curative therapy of pediatric acute leukemias and many solid tumors… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE The antibody-drug conjugate trastuzumab-DM1 (T-DM1) combines the biologic activity of trastuzumab with targeted delivery… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Trastuzumab-DM1 (T-DM1) is an antibody-drug conjugate that uses trastuzumab to specifically deliver the maytansinoid… (More)
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2008
2008
As a consequence of multiple functions of p53, its activation in response to cytotoxic stress may have proapoptotic or protective… (More)
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2006
2006
We have shown previously that EM011, a synthetic compound, binds tubulin with a higher affinity than the founding compound… (More)
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2003
2003
Because the aberrantly activated phosphoinositide 3-kinase (PI3K)/Akt pathway renders tumor cells resistant to cytotoxic insults… (More)
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1994
1994
Cryptophycin is a cytotoxic dioxadiazacyclohexadecenetetrone isolated from cyanobacteria of the genus Nostoc. Incubation of L1210… (More)
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Highly Cited
1991
Highly Cited
1991
Taxol, an antimicrotubule agent, has shown promise for efficacy in treatment of breast cancer, but severe hypersensitivity… (More)
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